Merck Sharp + Dohme Corp.

Lawrence Livermore National Security, LLC

Epigen Biosciences, Inc.

Suk Joong Lee

John M Finn

Xiaoming Li

Junhu Zhang

Zhiyong Chen

Leslie William Tari

Thanh To Lam

Michael Trzoss

Sergio E Wong

Felice C Lightstone

Daniel Bensen

Toan B Nguyen

Michael E Jung

Douglas W Phillipson

Min Teng

Chandravadan R Shah

Fabio C Tucci

Allen Borchardt

Graham Beaton

Satheesh Babu Ravula

Paul Aristoff

John F Finn

Voon Ong

Allen John Borchardt

Pyrimidine and Pyridine containing compounds are described herein that are enzyme p70S6K inhibitors useful in the treatment of S6K-dependent or S6K-mediated diseases and conditions, including but not limited to cancer, fibrotic metabolic and certain neurological disorders.

Pyrimidine and pyridine amine compounds and usage thereof in disease treatment

Disclosed herein are compounds having the structure of Formula I and pharmaceutically suitable salts, esters, and prodrugs thereof that are useful as antibacterially effective tricyclic gyrase inhibitors. In addition, species of tricyclic gyrase inhibitors compounds are also disclosed herein. Related pharmaceutical compositions, uses and methods of making the compounds are also contemplated.

Tricyclic Gyrase inhibitors

Disclosed herein are compounds having the structure of Formula I and pharmaceutically suitable salts, esters, and prodrugs thereof that are useful as antibacterially effective tricyclic gyrase inhibitors. Related pharmaceutical compositions, uses and methods of making the compounds are also contemplated.

Tricyclic gyrase inhibitors

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San Diego, CA, United States of America

Suk Joong Lee