Chinese Academy of Medical Sciences

Sujuan Sun

Donghui Wang

Zhen Chen

Qian Jack Liu

Chun Li

Quan Liu

Yuling Liu

Xuejun Xia

Renyun Wang

Dali Yin

Weijun Wang

Mingzhi Xie

Haifan Liu

Ruiwu Liu

Wuyan Zhang

Hongju Fang

Jiyu Guo

Yueteng Chen

Zhufang Shen

Qian Liu

The present invention relates to an effective fraction of alkaloids and the effective fraction is prepared from mulberry twig and its active ingredients are a composition of alkaloids. Determined by HPLC, the percentage of the total alkaloids are 50% or more by weight in the effective fraction and the percentage of the compound 1-deoxynojirimycin is 30% or more by weight in the total alkaloids. The effective fraction of the invention is prepared as the following steps: the mulberry twig is extracted by solvents, and the extract is precipitated by alcohol precipitation or flocculation to remove the impurities, and then concentrated, purified by resin chromatography. The present invention also relates to a pharmaceutical composition containing the said effective fraction of alkaloids and to the use of the effective fraction of alkaloids according to claim-in preparing hypoglycemic agents.

Use of the effective fraction of alkaloids from mulberry twig in preparing hypoglycemic agents

The compound represented by formula (I), in which the substitutes are defined as in the specification and the claims, or their stereoisomers, the process for preparing them, pharmaceutical composition containing them and their use as medicine.

Agarofuan derivatives, their preparation, pharmaceutical composition containing them and their use as medicine

Growing community of inventors

Beijing, China

Sujuan Sun