Research Development Foundation

Research Development Corporation

Imgenex

Sujay Singh

Bharat B Aggarwal

Bryant G Darnay

Peter Dias

The present invention provides cell permeable NF-&#x3ba;B inhibitors consist of a polypeptide derived from the p65 subunit of NF-&#x3ba;B and a protein transduction domain derived from antennapedia third helix sequence. The inhibitor suppressed NF-&#x3ba;B activation induced by TNF, LPS, IL-1, okadaic acid, PMA, HOand cigarette smoke condensate. NF-&#x3ba;B-regulated reporter gene expression induced by TNF, TNFR1, TRADD, TRAF2, NIK, IKK and p65 was suppressed by the inhibitor. The inhibitor enhanced TNF- and chemotherapeutic agent-induced apoptosis. Overall these results demonstrate a NF-&#x3ba;B inhibitor that can selectively inhibit NF-&#x3ba;B activation induced by various inflammatory stimuli, downregulate NF-&#x3ba;B mediated gene expression and upregulate apoptosis.

Selective inhibitors of nuclear factor-&#x3ba;B activation and uses thereof

The present invention provides a RANK (receptor activator of NF-&#x3ba;B) inhibitor consisted of a TRAF-6 (TNF receptor-associated factor-6) binding domain attached to a leader sequence. The peptide inhibitor inhibits RANKL (RANK ligand)-mediated osteoclast differentiation, thus indicating that targeted disruption of interaction between RANK and TRAF6 may prove useful as a therapeutic for metabolic bone disorders, leukemia, arthritis, and metastatic cancer of the bone.

Inhibitors of receptor activator of NF-&#x3ba;B and uses thereof

A method for diagnosing clinically distinct embryonal and alveolar subtypes of rhabdomyosarcoma, including contacting a reagent including an antibody that specifically binds myogenin with a sample that includes at least one rhabdomyosarcoma cell or at least one extract of at least one rhabdomyosarcoma cell, detecting the binding of the antibody to the sample to determine the presence, absence, or amount of myogenin in the sample, and diagnosing clinically distinct embryonal and alveolar subtypes of rhabdomyosarcoma, alveolar rhabdomyosarcoma having an increased amount of binding as compared to embryonal rhabdomyosarcoma.

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San Diego, CA, United States of America

Sujay Singh