Allergan, Inc.

Dermavant Sciences Gmbh

Arch Personal Care Products L.p.

Skinmedica, Inc.

Sujatha Sonti

Rahul C Mehta

Michael Quinn Doherty

Jon Lenn

Joey Roger Thomas

Piyush Jain

Leandro Santos

Justin Whiteman

Mary Bedard

John Anthony Garruto

Elizabeth Tsin Ho Makino

James Vincent Gruber

Smitha Rao

Lora Colvan

Justin E Whiteman

Leandro L Santos

Rahul Mehta

Elizabeth Tsin Makino

Jon D Lenn

The present invention relates to topical pharmaceutical emulsion compositions comprising a therapeutically effective amount of 3,5-Dihydroxy-4-isopropyl-trans-stilbene or a pharmaceutically acceptable salt thereof, an oil phase, a water phase, a surfactant, and an antioxidant, and wherein the emulsion composition is homogeneous and/or the active is solubilized in the oil phase. The invention also relates to methods of treating a dermatological condition or disorder in a patient by administering the present compositions to the skin of the patient.

Topical pharmaceutical compositions

The present invention provides a skin peel composition including a plurality of substances, such as lactic acid, salicylic acid, and resorcinol and, additionally a post-inflammatory hyper pigmentation reducing substance such as a retinol (vitamin A) or retinol derivative. Skin is first prepared using an alcohol preparation followed by a combinations of acids and, lastly, a retinol or retinol derivatives. Other agents such as ascorbic acid (vitamin C) and vitamin E can be added as needed. Application of the skin peel composition may be either topically in the form of a cream or gel, and may further be injected subcutaneously into the skin to achieve deeper penetration of the composition within the skin layers of the area to be treated.

Compositions for skin exfoliation and use thereof

Compositions comprising metabolized conditioned growth medium and/or metabolized cell extract and methods of use are described. The metabolized conditioned growth medium and metabolized cell extract compositions may be formulated with an acceptable carrier into injectable or topical formulations, for example, as a cream, lotion or gel, and may be used in cosmeceutical or pharmaceutical applications. The metabolized conditioned growth medium and metabolized cell extract may also be further processed to concentrate or reduce one or more factors or components contained within the metabolized conditioned growth medium or metabolized cell extract. The growth medium may be conditioned by any eukaryotic cell. The metabolized conditioned growth medium and metabolized cell extract may be used to prevent or treat a condition, for example, a skin condition.

Process for preparing metabolized conditioned growth media

Topical composition

A method for the modification of melanin distribution, and the composition thereof to modify melanin distribution are disclosed. A method for the reduction of melanin distribution, and the composition thereof to reduce melanin distribution are disclosed. A representative composition comprises 4-ethoxybenzaldehyde and one or more additional active agents as well as a pharmaceutically acceptable carrier or excipient. Carriers and excipients may be formulated for topical administration. Compositions may also be formulated for transdermal administration. The compositions may be used for the prevention and treatment of pigmentation disorders, by way of non-limited example, post-inflammatory hyperpigmentation and others. The compositions may be used for lightening skin.

Melanin modification compositions and methods of use

Growing community of inventors

San Marcos, CA, United States of America

Sujatha Sonti