Guangzhou Cellprotek Pharmaceutical Co., Ltd

Guangzhou Virotech Pharmaceutical Co., Ltd.

Suizhen Lin

Guangmei Yan

Jun Hu

Wei Yin

Jingxia Zhang

Kai Li

Xiao Xiao

Yuan Lin

Jiankai Liang

Haipeng Zhang

Xinhua Li

Wenbo Zhu

Yijun Huang

Jing Cai

Yaqian Tan

Shoufang Gong

Bingzheng Lu

Longxiang Sheng

Minyu Xie

Disclosed is use of 5α-androst-3β,5,6β-triol or an analogue, a deuterated compound or a pharmaceutically acceptable salt thereof in the manufacture of a medicament for the treatment of cerebral small vessel disease in a patient. The cerebral small vessel disease is preferably cerebral microbleed. The cerebral microbleed is spontaneous cerebral microbleed, drug-related cerebral microbleed, or traumatic cerebral microbleed. The present invention demonstrates that these compounds significantly enhance the clearance of extravascular hemoglobin, and thus can be used to treat cerebral small vessel disease.

Use of compound in preparation of drug for treating cerebral small vessel disease

Disclosed is a use of 5&#x3b1;-androstane-3&#x3b2;,5,6&#x3b2;-triol, an analogue, a deuterated derivative, and a pharmaceutically acceptable salt thereof in manufacture of a medicament for the treatment of hemorrhagic stroke in a patient. The hemorrhagic stroke is intracerebral hemorrhage or subarachnoid hemorrhage.

Use of compounds in preparation of a medicament for treatment of hemorrhagic stroke

The present invention belongs to the field of biomedicine and relates to use of VCP (valosin-containing protein, VCP) inhibitor and oncolytic virus in the preparation of an anti-tumor drug. The present invention firstly discovers that VCP inhibitor can be used in the preparation of an anti-tumor synergist for oncolytic virus. Meanwhile, the present invention relates to a pharmaceutical composition comprising VCP inhibitor and oncolytic virus, a pharmaceutical kit comprising VCP inhibitor and oncolytic virus, and use of VCP inhibitor and oncolytic virus for treating tumor, especially a tumor that is not sensitive to oncolytic virus. The present invention also relates to an anti-tumor administration system, characterized in that, comprising oncolytic virus and a reagent for detecting the expression level of VCP.

Use of VCP inhibitor and oncolytic virus in the preparation of an anti-tumor drug

Disclosed is use of alphavirus in preparation of antitumor drugs. The alphavirus is M1 virus or Getah virus. In addition, the specific tumor types sensitive to abovementioned alphavirus treatment are further determined, so as to provide a safe and effective solution for antitumor drug administering schemes.

Use of alphavirus in preparation of antitumor drugs

Described herein is use of a Caspase activator and an oncolytic virus in the preparation of an anti-tumor drug. As described, Caspase activator can enhance the anti-tumor effect of oncolytic virus, and the combination of Caspase activator and oncolytic virus produces a significant synergistic anti-tumor effect, and demonstrates an effective therapy for the treatment of tumors that are less sensitive to other pharmaceutical treatments.

Use of IAP inhibitor and oncolytic virus in preparation of anti-tumor drug

The present invention relates to four crystalline forms (crystalline forms A, B, C and D) of 5&#x3b1;-androstane-3&#x3b2;,5,6&#x3b2;-triol (YC-6) and preparation methods therefor. The four crystalline forms have significant difference in their lattice parameters, 2&#x3b8; values and intensity in X-ray power diffraction, and melting points, etc. The study on its polymorphism is very important for further studying its effect, bioavailability and stability.

Crystalline forms of 5&#x3b1;-androstane-3&#x3b2;,5,6&#x3b2;-triol and preparation methods therefor

The present invention discloses compound 2&#x3b2;,3&#x3b1;,5&#x3b1;-trihydroxy-androst-6-one, having the structure of formula (I). The present invention also discloses a plurality of methods for preparing the compound and a use of the compound. 

2&#x3b2;,3&#x3b1;,5&#x3b1;-trihydroxy-androst-6-one and preparation methods and use thereof

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Guangzhou, China

Suizhen Lin