Sangstat Medical Corporation

University of California

Suhasini Iyer

Roland Buelow

Jacky Woo

Satya Dandekar

Methods are provided wherein the survival of an organ transplant is enhanced by introducing into cells of the transplant a nucleic acid molecule that modulates heme oxygenase-I activity therein. Nucleic acid molecules that modulate heme oxygenase-I activity and therefore find use in the described methods include, for example, molecules that encode a polypeptide that itself exhibits heme oxygenase-I activity or antisense oligonucleotides that act to inhibit heme oxygenase-I activity in a cell.

Methods for enhancing graft survival by modulating heme oxygenase activity

The present invention relates to pharmaceutical preparations and methods for treating individuals infected with the human immunodeficiency virus (HIV). The pharmaceutical preparations comprise an immunomodulating agent and a anti-retroviral compound. The pharmaceutical preparations are used to treat HIV infected patients, particularly for gastrointestinal complications arising from viral infection. In addition, the pharmaceutical preparations of the present invention have the effect of raising the levels of CD4single positive and CD4and CD8double positive T cells, thus promoting restoration and normalization of the immune system following HIV infection.

Combined therapy for treatment of HIV infection

Metalloporphyrins are administered in conjunction with transplantation to enhance the survival of the organ.

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San Ramon, CA, United States of America

Suhasini Iyer