Lupin, Inc.

Suhas Ganpat Tambe

Girij Pal Singh

Gurvinder Pal Singh

Himanshu Madhav Godbole

Sagar Purushottam Nehate

Purna Chandra Ray

Umesh Babanrao Rananaware

Vilas Nathu Dhake

Narotham Maddireddy

Harischandra Sambhaji Jadhav

Bhushan Bhanudas Kirange

A process for preparation of optically pure or optically enriched enantiomers of sulphoxide compounds of formula (I), such as omeprazole and structurally related compounds, as well as their salts and hydrates. The said process comprises 

Process for the preparation of optically pure or optically enriched enantiomers of sulphoxide compounds

A dicyclohexyamine salt of compound of formula I, namely perindopril, having an X-ray powder diffraction pattern with characteristic peaks (2&#x3b8;): 8.462, 10.624, 18.693, 9.424, 17.272, 14.177, 19.499, 20.765, 21.409, and 14.540.  A process for preparation of the said salt of perindopril and its use in the purification of an impure perindopril and a process for purification of perindropril comprising formation of its salt with dicyclohexylamine. The present invention also relates to preparation of Perindopril tert-butyl amine salt directly from Perindopril dicyclohexylamine salt without isolating the free base.

Process for the purification of perindopril

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Pune, India

Suhas Ganpat Tambe