Honda Giken Kogyo Kabushiki Kaisha

Nippon Steel Corporation

Nippon Steel Sumitomo Metal Corporation

Honda Motor Co., Ltd.

Jnc Corporation

Tokyo Medical and Dental University

Kyoto University

Eagle Industry Co., Ltd.

Nippon Light Metal Company, Ltd.

Kagoshima University

Suguru Yoshida

Takamitsu Hosoya

Manabu Kubota

Hirokazu Sugiyama

Toshiharu Aiso

Yoshiyuki Watanabe

Masakazu Sato

Satoshi Inouye

Shoichi Sano

Yasushi Hasegawa

Kei Miyanishi

Masatoshi Hagiwara

Kazuo Watanabe

Yuiko Miura

Kohki Sugawara

Kohichi Yamamoto

Kouji Enomoto

Yoshinobu Ono

Hiroshi Kita

Akira Shiga

Tatsuya Koyama

Hajime Kajiwara

Hideki Matsuda

Toshimi Tarui

Hajime Hasegawa

Tadashi Ohya

Teruyuki Wakatsuki

Takeshi Matsushita

Isao Kii

Hideo Mizukami

Masahiro Saitoh

Keiichi Obata

Teruhisa Okumura

Koki Mizuno

Kazuo Inoue

Takashi Kurihara

Yutaka Neishi

Masaharu Ueda

Masami Ogura

Tsuneo Konno

Yuta Urushiyama

Shinya Teramoto

Keiichi Sugiyama

Takahisa Suzuki

Shuji Kozawa

Kenichi Nagahiro

Isao Tsunoda

Hiromasa Takada

Teruhisa Miyazaki

Takashi Chirifu

Masaki Mizoguchi

Noriyuki Matsuda

Tateo Kawade

Hideyuki Murakami

Hiroo Shimada

Katsuaki Taguchi

Takuya Yamanaka

Hiroyuki Hasegawa

Shigeo Fujita

Harumichi Hino

Yuto Sumida

Hiroyuki Saegusa

Hironori Satoh

Masafumi Kato

Shigeru Kohmura

Koji Enomoto

Kouichi Yamamoto

Tadayoshi Okada

Ken Uchida

Masao Ohno

Tadatoshi Aoyama

Masanori Suganuma

Yuuji Saitou

Minoru Mouko

Shigeomi Shimizu

Mituo Tuge

Masayasu Toyomoto

Michiko Murohashi

Kita Hiroshi

Akiko Kobayashi

Munehiro Mouri

Masahiro Hashiguchi

A communication control device comprises: a determination unit configured to determine whether a target has approached a mobile object based on information detected by a sensor mounted on the mobile object; and a communication control unit configured to control a communication unit that calls a call center based on a determination result by the determination unit, wherein the communication control unit causes transmission, to the call center, of first information relating to information detected at the mobile object while making a call connection to the call center, which is started in response to a call.

Communication control device, mobile object, communication control method, and computer-readable storage medium

A reporting device includes an emergency reporting section that sends, to a response system via a communication control section, first emergency information including at least one of no-occupant information indicating that no occupant is present in a moving body and autonomous driving mode setting information indicating that the moving body is set in an autonomous driving mode when recognizing that a shock has occurred in the moving body based on shock occurrence information while it is recognized by a driving mode recognizing section that the moving body is set in the autonomous driving mode and it is recognized by an occupant recognizing section that no occupant is present in the moving body.

Reporting device sending collision information based on driving mode and occupant presence

There is provided a spring steel including predetermined chemical composition, in which ([Ti mass %]&#x2212;3.43&#xd7;[N mass %])/[S mass %]&#x3e;4.0, and [Ni mass %]+[Cu mass %]&#x3c;0.75 are satisfied, and an appearance frequency of MnS is less than 20% among inclusions having an equivalent circle diameter of 1 &#x3bc;m or more which are observed at a &#xbc; position of a diameter from a surface.

Spring steel

Provided is a composition for activating neurogenesis, use of the composition, and a method for preventing, improving, inhibiting the development of, and/or treating a disease or the like of the central nervous system and or the peripheral nervous system using the composition. A composition for activating neurogenesis contains, as an active ingredient, a compound having an ability to inhibit phosphorylation activity of a protein kinase or a prodrug thereof, or a pharmaceutically acceptable salt thereof, and a composition for preventing, improving, inhibiting the development of, and/or treating a disease of the central nervous system and/or the peripheral nervous system, or for improving, inhibiting the development of, and/or treating a functional disorder of the central nervous system and/or the peripheral nervous system, the composition containing, as an active ingredient, a compound having an ability to inhibit phosphorylation activity of a protein kinase or a prodrug thereof, or a pharmaceutically acceptable salt thereof.

Composition for activating neurogenesis

It has been found that efficient screening for a compound having anticancer activity can be achieved by selecting a compound having activity to induce alternative autophagy using, as an index, formation of fluorescent bright spots due to aggregation of a lysosomal protein to which a fluorescent protein is attached in cells expressing the lysosomal protein. In addition, it has been found that a benzothiophene compound represented by the following general formula (1) has alternative autophagy-inducing activity and anticancer activity: 

Benzothiophene compound, alternative autophagy-inducing agent and anticancer agent including the compound as active ingredient, and method for screening for compound having anticancer activity

There is provided a hot forging steel including, by mass %, C: more than 0.30% and less than 0.60%, Si: 0.10% to 0.90%, Mn: 0.50% to 2.00%, S: 0.010% to 0.100%, Cr: 0.01% to 1.00%, Al: more than 0.005% and 0.100% or less, N: 0.0030% to 0.0200%, Bi: more than 0.0001% and 0.0050% or less, Ti: 0% or more and less than 0.040%, V: 0% to 0.30%, Ca: 0% to 0.0040%, Pb: 0% to 0.40%, and a remainder including Fe and impurities, in which P and O in the impurities are respectively P: 0.050% or less and O: 0.0050% or less, an expression d+3&#x3c3;&#x3c;20 is satisfied, and a presence density of MnS having an equivalent circle diameter of smaller than 2.0 &#x3bc;m is 300 pieces/mmor more in a cross section parallel to a rolling direction of a steel.

Hot forging steel and hot forged product

A steel for induction hardening according to an aspect includes, as a chemical composition, predetermined amounts of alloy elements and a remainder including Fe and impurities, in which Al&#xd7;N is 0.000330 to 0.000825, Mn/S is 4.6 to 14.0, a machinability index M is 15.5 to 25.65, an area fraction of AlN having an equivalent circle diameter of more than 200 nm at a &#xbc; position of a diameter of the steel is 20% or less of an area fraction of all AlN having an equivalent circle diameter of 40 nm or more, and a number density of Mn sulfide-based inclusions having a maximum diameter of 0.3 &#x3bc;m or more and 10 &#x3bc;m or less at the &#xbc; position of the diameter is 100 pieces/mmor more and 2500 pieces/mmor less.

Steel for induction hardening

There is a hot-rolled steel according to one aspect of the invention including predetermined chemical compositions including 0.0001 to 0.0050 mass % of Bi, in which 90 area % or more of a metallographic structure is configured with a ferrite and a pearlite, and an average number density of Mn sulfides extending along a rolling direction and having an aspect ratio exceeding 10 and equal to or smaller than 30, which is measured on a cross section parallel to the rolling direction, is 50 to 200 number/mm.

Hot-rolled steel and steel component

A soft nitrided induction hardened steel part which is excellent in bearing fatigue strength comprised of a predetermined chemical composition wherein a dissolved N concentration from the surface to 0.2 mm depth is 0.05 to 1.50%, a Vicker's hardness from the surface to 0.2 mm depth after tempering at 300&#xb0; C. is HV 600 or more, and t/r&#x2264;0.35 when an effective hardened layer depth 't' is 0.5 mm or more and a radius of a breakage risk site or half of the thickness is 'r' (mm).

Soft nitrided induction hardened steel part

Disclosed is a lip seal for water pump made of a rubber-like elastic material, fixed to a housing as a fixed side and in sliding contact with a shaft rotating relative to the housing; the lip seal having sliding surface with a surface roughness Ra (according to JIS B0601 corresponding to ISO 4287) of 1 to 30 &#x3bc;m, being obtained by vulcanization-molding of a rubber composition comprising 100 parts by weight of the rubber-like elastic material, 1 to 150 parts by weight of a reinforcing filler, 5 to 90 parts by weight of a non-reinforcing filler having an average particle diameter of 1 &#x3bc;m or more, 0.1 to 5 parts by weight of a coupling agent, 1 to 15 parts by weight of a co-crosslinking agent, and 0.5 to 10 parts by weight of an organic peroxide. The lip seal effects to prevent softening and volume swelling of the rubber-like elastic material and furthermore the generation of deposits in the rotating shaft, which are problematic for rotation torque and LLC resistance.

Lip seal for water pump

Steel for forging having high strength and superior machinability due to controlled cooling immediately after shaping by hot forging followed by tempering and having a lower specific gravity than ordinary steel for forging use, the steel containing C: 0.05 to 0.50%, Si: 0.01 to 1.50%, Mn: 3.0 to 7.0%, P: 0.001 to 0.050%, S: 0.020 to 0.200%, Al: 3.0 to 6.0%, Cr: 0.01 to 1.00%, and N: 0.0040 to 0.0200% and having a balance of Fe and unavoidable impurities.

Low specific gravity steel for forging use excellent in machineability

A Roughly shaped material for induction hardened components including: a. steel as a base metal including, as a chemical composition, by mass %, C: 0.35% to 0.6%, Si: 0.02% to 2.0%, Mn: 0.35% to 1.5%, Al: 0.001% to 0.5%, Cr: 0.05% to 2.0%, S: 0.0001% to 0.05%, N: 0.003% to 0.0120%, P: 0.03% or less, O: 0.0050% or less, an iron nitride layer having a thickness of 0.1 &#x3bc;m to 50 &#x3bc;m in a depth direction is formed at a surface, and a volume fraction of a &#x3b3;' phase, which is a Fe nitride, in the iron nitride layer, is 80% or more.

Roughly shaped material for induction hardened components and method for producing same

A compound and a pharmaceutical composition for disease associated with an abnormal splice variant, use of the compound and the pharmaceutical composition, or a screening method of the compound and the pharmaceutical composition are provided. One or more embodiments disclose a compound expressed by the following formula (I) or (I') or prodrugs or pharmaceutically acceptable salts thereof. Another one or more embodiments disclose a screening method using a DNA construct that is fused, arranged, or constructed so as to express different reporter genes for a wild-type splice variant and an abnormal splice variant that contributes to the development or progression of disease; 

Method for screening substance capable of inhibiting abnormal splicing causative of onset or progress of disease

Provided is a pain-related compound, a pain-related pharmaceutical composition, and use of the same. Provided in one or more embodiments is a compound represented by Formula (I), a prodrug of the same, or a pharmaceutically permissible salt of any of the same. 

Pain-related compound and medical composition

The invention aims in establishing a method for modifying biomolecules using a reaction that efficiently modifies biomolecules and is widely applicable. The invention thus provides a cyclic compound containing two triazole rings formed by adding and ligating an azide compound possessing an azido group to each of the two carbon-carbon triple bond sites of an eight-membered cyclic skeleton of a cyclic diyne compound by a double click reaction; a method for producing a cyclic compound using a double click reaction; and a method for modifying biomolecules.

Cyclic compound, method for producing cyclic compound, and method for modifying biological molecule

Growing community of inventors

Tokyo, Japan

Suguru Yoshida