Riken Corporation

Sumitomo Pharma Co., Ltd.

Sumitomo Chemical Company, Limited

Sumitomo Dainippon Pharma Co., Ltd.

Racthera Co., Ltd.

Suguru Yamasaki

Masayo Takahashi

Yoshiki Sasai

Atsushi Kuwahara

Yasushi Hiramine

Michiko Mandai

The present invention provides a method for producing neural cells or a neural tissue, including the following steps (1)-(3): (1) a first step of culturing pluripotent stem cells in the absence of feeder cells and in a medium containing 1) a TGFβ family signal transduction pathway inhibiting substance and/or a Sonic hedgehog signal transduction pathway activating substance, and 2) a factor for maintaining undifferentiated state,(2) a second step of culturing the cells obtained in the first step in suspension to form a cell aggregate, and(3) a third step of culturing the aggregate obtained in the second step in suspension in the presence or absence of a differentiation-inducing factor to obtain an aggregate containing neural cells or a neural tissue.

Production method for nerve tissue

The present invention provides a method for producing retinal cells or a retinal tissue, comprising the following steps (1)-(3):

Production method for retinal tissue

An object of the present invention is to provide a cell population suitable for transplant of retinal tissue and a method of production thereof. The present invention provides a cell population for transplant, comprising retinal cells with a modified bipolar cell-regulating gene and a method of production thereof.

Human cell population comprising human retinal progenitor cells without an ISL1 gene for transplantation and methods of use thereof

A sphere-like cell aggregate according to one embodiment of the present invention comprises: a core part containing neural retina; and a covering part continuously or discontinuously covering at least a portion of a surface of the core part.

Cell aggregate including retinal tissue and production method therefor

The present invention provides a method for producing a retinal cell or a retinal tissue, including the following steps (1)-(3):

Method for producing retinal tissue

The present invention provides a method for producing neural cells or a neural tissue, including the following steps (1)-(3):

Growing community of inventors

Kobe, Japan

Suguru Yamasaki