Daiichi Sankyo Company, Limited

Daiichi Sankyo Europe Gmbh

Suguru Ueno

Thore Hettmann

Reimar Abraham

Sabine Blum

Yoshinobu Shiose

Kumiko Koyama

To provide an antitumor drug having excellent therapeutic effect, which is excellent in terms of antitumor effect and safety. Provided is an antibody-drug conjugate in which an antitumor compound represented by the following formula is conjugated to an anti-HER3 antibody via a linker having a structure represented by the formula: -L-L-L-NH&#x2014;(CH)n-L-(CH)n-C(&#x2550;O)&#x2014; or -L-L-L- (the anti-HER3 antibody is connected to the terminal of L, the antitumor compound is connected to the carbonyl group of &#x2014;(CH)n-C(&#x2550;O)&#x2014; moiety or the C terminal of L, with the nitrogen atom of the amino group at position 1 as a connecting position). 

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Tokyo, Japan

Suguru Ueno