Zymogenetics, Inc.

Eisai Company, Limited

Rakuten, Inc.

Suguru Suzuki

Shinji Yoshitake

Eileen R Mulvihill

Akira Hashimoto

Teruaki Yuzuriha

Bjorn A Nexo

Yasunori Ikeda

Yoshiharu Mizui

Naoko Nagaoka

Tetsuya Tajima

Toshio Seto

Hiroyuki Kato

Noritoshi Sano

Yasushi Kontani

Yusuke Yamakawa

Noboru Suzuki

A managing device () includes an editor () that causes a store to edit a product page for the store to sell a product, and to allocate a category name to the product page, a presenter () that searches a result page matching a query entered by a customer through the edited product page, and presents the result page to the customer, a register () that registers, when the product is purchased by the customer through the presented result page, a character string contained in the query with a page history in association with the result page, and a calculator () that calculates, based on a registration frequency with the page history for the category name allocated to the result page in association with the page history, a parameter indicating whether or not the allocation of the category name to the result page is suitable.

Managing device, managing method, recording medium, and program

To provide a comment submission support system capable of supporting submission of such a comment as to enable a person who has viewed the comment to grasp a purchase status of a product or service. A purchase status information acquisition unit () acquires purchase status information relating to a purchase status of a product or service that is sold by a sales method in which a unit price of the product or service purchased by a plurality of purchasers within a target period is determined based on a total number of purchases of the product or service purchased by the plurality of purchasers within the target period. A transmission unit () transmits link information for access to a communication service device and information based on the purchase status information to a terminal of a user. The link information and the information based on the purchase status information are used by the terminal of the user to request the communication service device for submission screen data being such data as to automatically input the comment relating to the purchase status of the product or service to a comment input field.

Comment submission support system, comment submission support device, comment submission support device control method, program, and information storage medium

Tissue plasminogen activator analogs containing the growth factor domain of native t-PA, the domain having at least one cysteine residue replaced with another amino acid. The t-PA analogs may further contain a variety of substitutions and/or modifications. Pharmaceutical compositions containing one or more of the t-PA analogs along With a physiologically acceptable carrier or diluent are also disclosed.

Tissue plasminogen activator analogs having modified growth factor

A novel human antithrombin III (AT III) mutant having a high antithrombin activity in the absence of heparin and effective in the treatment of thrombotic disorders as an anticoagulant, which is obtained by mutating amino acids at the reactive site and the heparin binding site of human AT III into another amino acids with the use of the recombinant DNA technology with the use of a DNA coding for AT III as a template. The invention also relates to a method for mass producing the above-described mutant by incubating a host transformed by an expression vector having the cDNA of the mutant inserted therein.

Human antithrombin III mutants

Tissue plasminogen activator analogs exhibiting greater specificity for fibrin than native t-PA are disclosed. The analogs include the K1 domain of native t-PA replaced with another kringle domain mediating the binding of the analog to fibrin. The kringle contains six cysteine residues. The t-PA analogs may further include a variety of substitutions and modifications. Pharmaceutical compositions containing one or more of the t-PA analogs along with a physiologically acceptable carrier or diluent are also disclosed.

Modified t-PA with kringle-/replaced by another kringle

An anticoagulant containing heparin having low antithrombin III affinity as an effective ingredient.

Anticoagulant

Growing community of inventors

Tokyo, Japan

Suguru Suzuki