Other

University of Pittsburgh

Carnegie Mellon University

Eye & Ear Foundation

Sufi Mary Thomas

Danith H Ly

Jennifer Rubin Grandis

A class of antisense agents having a distributed guanidinium peptide nucleic acids (GPNA) backbone which has excellent uptake into mammalian cells, can bind to the target DNA or RNA in a highly sequence specific manner and can resist nucleases and proteases both outside and inside the cell(s) of interest. In one embodiment, either systemic or intratumoral administration of antisense Epidermal Growth Factor Receptor ('EGFR') GPNA oligonucleotides is believed to downmodulate EGFR levels, thus in turn to reduce head and neck squamous cell carcinoma tumor growth, which has been confirmed to date both in vitro and in vivo.

Growing community of inventors

Cheswick, PA, United States of America

Sufi Mary Thomas