Massachusetts Institute of Technology

The Brigham and Women's Hospital, Inc.

Sufeng Zhang

Robert Samuel Langer

Omid C Farokhzad

Jeffrey Michael Karp

Praveen Kumar Vemula

Nathaniel R Campbell

Abdullah M Syed

Carlo Giovanni Traverso

Robert S Langer, Jr

Joshua Korzenik

Ashok Kakkar

Compositions, articles, and methods for targeted drug delivery, such as thermoresponsive hydrogel polymers, are generally provided. In one aspect, the compositions and articles comprise a thermoresponsive hydrogel polymer comprising a releasable therapeutic agent. In some cases, the compositions described herein have advantageous combinations of properties including mechanical strength, biocompatibility, tunable charge densities, thermal responsiveness, drug loading, and/or configurations for targeted drug delivery. In one embodiment, the composition comprises a solution comprising a thermoresponsive polymer including one or more ligands attached to the polymer, wherein the solution is configured to undergo a sol-to-gel transition under physiological conditions. In another embodiment, the composition comprises a plurality of nanoparticles e.g., associated with the thermoresponsive polymer. In yet another embodiment, the composition comprises a therapeutic agent e.g., associated with the nanoparticles and/or thermoresponsive polymer.

Compositions and related methods for targeted drug delivery

Self-assembled gel compositions including a gelator, e.g., an enzyme-cleavable gelator, e.g., having a molecular weight of 2500 or less, are described. The self-assembled gel compositions can encapsulate one or more agents. Methods of making the self-assembled gel compositions, and methods of drug delivery using the self-assembled gel compositions are also described.

Nanostructured gels capable of controlled release of encapsulated agents

Nanostructured gels capable of controlled release of entrapped agents

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Cambridge, MA, United States of America

Sufeng Zhang