Qingdao Kingagroot Chemical Compound Co., Ltd.

Sudong Mo

Lei Lian

Lei Wang

Bo Chen

Guizhi Liu

Junjie Zhang

Dehui Ding

Chao Song

Guangdi Yuan

Huarong Li

Zhenguo Li

The present invention relates to a mutant p-hydroxyphenylpyruvate dioxygenase (HPPD) protein or a bioactive fragment thereof and an isolated polynucleotide comprising a nucleic acid sequence encoding the protein or fragment thereof, wherein the mutant p-hydroxyphenylpyruvate dioxygenase (HPPD) protein or a bioactive fragment thereof retains or enhances the property of catalyzing the conversion of p-hydroxyphenylpyruvate (HPP) to homogentisate and is significantly less sensitive to HPPD-inhibiting herbicides than a wild-type HPPD. The present invention also relates to a nucleic acid construct, an expression vector and a host cell comprising the polynucleotide, as well as to a method for producing a plant that has the property of catalyzing the conversion of p-hydroxyphenylpyruvate (HPP) to homogentisate and significantly reduced sensitivity to HPPD-inhibiting herbicides.

Mutant p-hydroxyphenylpyruvate dioxygenase, and coding nucleic acid and use thereof

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Qingdao, China

Sudong Mo