University of Central Florida Research Foundation, Inc.

The Texas A&m University System

University of Colorado

University of Oklahoma

Sanford Burnham Prebys Medical Discovery Institute

Cc Technologies Laboratories, Inc.

Lockheed Martin Missiles & Fire Control

University of L'aquila

Other

Lockheed Martin Corporation

Duke University

Sudipta Seal

Swanand D Patil

Eric Petersen

David Reid

Suresh Chandra Kuiry

William Self

Sameer Deshpande

Soumen Das

Satyajit V Shukla

Bradley Jay Willenberg

Swetha Barkam

Hyoung Jin Cho

Weifeng Fei

Larry L Hench

Erik Brinley

Manas K Haldar

Janet Dowding

James F McGinnis

Lily L Wong

Ajay Karakoti

Meyya Meyyappan

Kiminobu Sugaya

Leslie David Kramer

Edit L Braunstein

William P Jepson

Stephanie Merchant

Matthew Stephens

Thomas Sammet

Sanku Malik

Alex Lepage

Dwight Towler

Annamaria Cimini

Barbara D'Angelo

Petya Georgieva

Manny Vrotsos

Rodolphe Carro

Suresh Babu Krishna Moorthy

Metthew Stephens

Alexander John Bosak

Robert Draper

Jason Arvanetes

Debasis Bera

Jennifer Small

Matthew Luke McCutchen

Junping Chen

Lawrence Ludwig

Steve Sezate

Ella Bossy-Wetzel

Alicia Renae Willenberg

Amitava Adhikary

Michael Bass

Anjum Mehta

Zeljko Vujaskovic

Isabel Lauren Jackson

Clara A Rivero

Sanku Mallik

Udit Kumar

Swanand H Patil

Craig Neal

Shailendra Giri

Cheryl H Baker

Robert Gorman

Kiminohu Sugaya

Kenneth Liechty

Ken Liechty

D Wayne Jenkins

Xiaohong Zhou

Peter Brenneisen

Abhilash Vincent

Beverly A Rzigalinski

Vijayalakshmi Shridhar

David Bailey

David L Reid

Lily Wong

James F Mcginnis

Cerium oxide nanoparticles (CNPs) have been proven to exhibit antioxidant properties attributed to its surface oxidation states (Ce4+ to Ce3+ and vice versa) mediated at the oxygen vacancies on the surface of CNPs. Different anions in precursor cerium salts were used to prepare CNPs resulting in disclosed CNPs with varying physicochemical properties such as dispersion stability, hydrodynamic size, and the signature surface chemistry. The antioxidant catalytic activity and oxidation potentials of different CNPs have been significantly altered with the change of anions in the precursor salts. For one, CNPs prepared using precursor salts containing NOand Clions exhibited increased antioxidant activity than previously thought possible. The change in oxidation potentials of CNPs with the change in concentration of the nitrate and chloride ions indicates the disclosed CNP's have different surface chemistry and antioxidant properties. These compositions and methods of their synthesis are disclosed.

Cerium oxide nanoparticle compositions and methods

An implant is provided comprising a substrate having one or more nanoceria coatings coated at least partially thereon, wherein the one or more nanoceria coatings comprise surface cerium having a 3+/4+ oxidation state ratio such that the one or more nanoceria coatings exhibit catalase mimetic activity, superoxide dismutase mimetic activity, or both. Methods are provided for forming a nanoceria coating. The coating has nanoceria having a surface cerium 3+/4+ oxidation state ratio such that such that the coating exhibits catalase mimetic activity, superoxide dismutase mimetic activity, or both. Also disclosed is a method of reducing degradation of an implant by placing nanoceria in proximity to a bone-implant interface.

Implant and coating to reduce osteolysis

The present disclosure relates to compositions and methods for enhancing mosquito feeding.

Compositions for neuromodulation of mosquito feeding behavior and uses thereof

The present disclosure relates to wound treatment and therapy and the promotion of tissue regeneration following injury. In particular, it relates to a microRNA-146a and nanoceria conjugate for improving wound healing and, in some embodiments, preventing adverse ventricular remodeling following myocardial infarction.

Use of microRNA-146A and nanoceria conjugate to improve wound healing and promote tissue regeneration

Disclosed are real-time insect surveillance sensor devices and methods that use a colorimetric readout for detecting insect disease vectors (such as mosquitoes which can transmit pathogens such as DENV, CHIKV, and ZIKV). The method involves an attractive or feeding solution combined with detector conjugates. The conjugate can specifically detect proteins present in insect saliva and/or proteins specific to mosquito-borne pathogens.

Passive insect surveillance sensor device

Disclosed herein is a nano-coating platform that is designed to 'capture' and 'kill' (i.e. inactivate) virus species to prevent surface to surface contamination/transmission and thereby the spread of novel viruses. The platform is comprised of alternating layers of charged polymers (producing a multi-layer coating). The cationic layer may be grafted with oligomeric species, chosen to bind strongly to unique/specific virus surface features, thereby mediating capture of the virus (with the choice of oligomeric species allowing generalization to a given virus). Natural light (excitation) to UV (local emission) up-converting nanoparticles are seeded into the anionic layer and mediate the inactivation (&#x2018;killing&#x2019;) of the bound virus species.

Coating for capturing and killing viruses on surfaces

Methods of protecting skin of a mammal by application of silk-derived compositions useful for treating or preventing a wide variety of skin conditions. Silk solutions and silk mats are prepared and applied to the skin surface. The silk compositions may be self-adhesive or sutured to cover a wound or area of skin exposed to physical stresses and strains, thereby preventing a wound and/or promoting wound healing.

Topical silk compositions and methods of using

Cerium oxide nanoparticles have been found to enhance radiation-induced cancer cell death, while at the same time protecting normal tissue from radiation. The combination of cerium oxide nanoparticles with radiation has also been found to control and/or minimize the metastatic index. Cerium oxide nanoparticles have also been found to protect normal tissue subjected to irradiation from inflammation, and further to protect cells from reactive oxygen species. A cream comprising cerium oxide nanoparticles is formulated and used to protect skin against radiation-induced dermatitis.

Cerium oxide nanoparticle formulation for use in skin radioprotection and associated methods

An implant is provided comprising a substrate having one or more nanoceria coatings coated at least partially thereon, wherein the one or more nanoceria coatings comprise surface cerium having a 3+/4+ oxidation state ratio such that the one or more nanoceria coatings exhibit catalase mimetic activity, superoxide dismutase mimetic activity, or both. Methods are provided for forming a nanoceria coaling. The coating has nanoceria having a surface cerium 3+/4+ oxidation state ratio such that such that the coating exhibits catalase mimetic activity, superoxide dismutase mimetic activity, or both. Also disclosed is a method of reducing degradation of an implant by placing nanoceria in proximity to a bone-implant interface.

A method of forming polymer composites includes mixing a transition metal oxide precursor including at least one transition metal, a polymer as a binder, a solvent for the polymer, and water to form a first solution including polymer-transition metal complexes. The polymer-transition metal complexes are hydrolyzed to produce a plurality of transition metal oxide nanoparticles, wherein water is added in the mixing in a stoichiometric excess for the hydrolyzing. The solvent and residual of the water remaining after the hydrolyzing are removed. A polymer composite including the transition metal oxide nanoparticles dispersed in the polymer results after the removing, where some of the polymer is chemically conjugated to a surface of the transition metal oxide nanoparticles.

Polymer composite having dispersed transition metal oxide particles

A method of forming polymer composites having transition metal oxide nanoparticles dispersed therein includes mixing a transition metal oxide precursor including at least one transition metal, a polymer as a binder, a solvent for the polymer, and water to form a first solution including polymer-transition metal complexes. The polymer-transition metal complexes are hydrolyzed to produce a plurality of transition metal oxide nanoparticles, wherein water is added in the mixing in a stoichiometric excess for the hydrolyzing. The solvent and residual of the water remaining after the hydrolyzing are removed. A polymer composite including a plurality of transition metal oxide nanoparticles dispersed in the polymer results after the removing, where some of the polymer is chemically conjugated to a surface of the transition metal oxide nanoparticles.

A method of treating a subject with elevated levels of peroxynitrite includes administering a therapeutically effective amount of cerium oxide nanoparticles to the subject, wherein the cerium oxide nanoparticles reduce the level of peroxynitrite in the subject.

Neuronal protection by cerium oxide nanoparticles

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Oviedo, FL, United States of America

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