Carnegie Mellon University

Akebia Therapeutics, Inc.

Sudhir Ranjan

Xiaoyang Wang

Birger Erik Ydstie

Sridhar Seetharaman

Balaji Sukumar

Provided herein are solid forms of {[5-(3-chlorophenyl)-3-hydroxypyridine-2-carbonyl]amino}acetic acid (Vadadustat, Code: AKB-6548, Compound 1), compositions comprising such solid forms, and methods of making and using thereof. 

Solid forms of {[5-(3-chlorophenyl)-3-hydroxypyridine-2-carbonyl]amino} acetic acid

A method for producing a solid layer material (), comprising providing () a first layer (); providing () a second liquid layer () on the first layer (); providing () a third liquid layer () on the second liquid layer (), wherein the third liquid layer has a melting point that is higher than a melting point of the second liquid layer, and wherein the second liquid layer is between the first and third layers; cooling () a surface of the third liquid layer to a temperature less than the melting point of the third liquid layer; forming () the solid layer from the third liquid layer while cooling the third layer liquid; and removing () the solid layer.

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Lexington, MA, United States of America

Sudhir Ranjan