Rutgers, the State University of New Jersey

Sudhir K Singh

Edmond Joseph LaVoie

Leroy Fong Liu

Alexander L Ruchelman

Abhijit Ray

The invention provides compounds of the invention pharmaceutical compositions comprising a compound of the invention, processes for preparing compounds of the invention, intermediates useful for preparing compounds of the invention, and therapeutic methods for treating cancer and other topoisomerase mediated conditions.

Cytotoxic agents

The invention provides compounds of formula I:wherein: R-R, 'a' and X have any of the meanings defined in the specification and their pharmaceutically acceptable salts. The invention also provides pharmaceutical compositions comprising a compound of formula I, processes for preparing compounds of formula I, intermediates useful for preparing compounds of formula I, and therapeutic methods for treating cancer using compounds of formula I.

Nitro and amino substituted heterocycles as topoisomerase I targeting agents

The invention provides compounds of formula I:wherein R&#x2013;R, W, and X have any of the meanings defined in the specification and their pharmaceutically acceptable salts. The invention also provides pharmaceutical compositions comprising a compound of formula I, processes for preparing compounds of formula I, intermediates useful for preparing compounds of formula I, and therapeutic methods for treating cancer using compounds of formula I.

Growing community of inventors

Bengaluru, India

Sudhir K Singh