Alnylam Pharmaceuticals, Inc.

Sudhakar Rao Takkellapati

Muthiah Manoharan

Kallanthottathil G Rajeev

Shigeo Matsuda

Alexander V Kelin

The present invention provides nucleosides of formula (1) and oligonucleotides comprising at least one nucleoside of formula (2): Another aspect of the invention relates to a method of inhibiting the expression of a gene in cell, the method comprising (a) contacting an oligonucleotide of the invention with the cell; and (b) maintaining the cell from step (a) for a time sufficient to obtain degradation of the mRNA of the target gene.

Nucleic acid chemical modifications

The present invention provides nucleosides of formula (1) and oligonucleotides comprising at least one nucleoside of formula (2): Another aspect of the invention relates to a method of inhibiting the expression of a gene in cell, the method comprising (a) contacting an oligonucleotide of the invention with the cell; and (b) maintaining the cell from step (a) for a time sufficient to obtain degradation of the mRNA of the target gene. 

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Cambridge, MA, United States of America

Sudhakar Rao Takkellapati