Other

Osiris Therapeutics, Inc.

Johns Hopkins University

Sudhakar Kadiyala

Scott Philip Bruder

Arnold I Caplan

Kam W Leong

David J Fink

David Jordan Fink

Hungnan Lo

Francis Peter Barry

Randell G Young

Lanfranco Callegaro

Luis A Solchaga

Roland Moskowitz

Jung U Yoo

Josephine Mary Murphy

Randall G Young

Giovanni Abatangelo

Disclosed are compositions and methods for augmenting bone formation by administering isolated human mesenchymal stem cells (hMSCs) with a ceramic material or matrix or by administering hMSCs; fresh, whole marrow; or combinations thereof in a resorbable biopolymer which supports their differentiation into the osteogenic lineage. Contemplated is the delivery of (i) isolated, culture-expanded, human mesenchymal stem cells; (ii) freshly aspirated bone marrow; or (iii) their combination in a carrier material or matrix.

Regeneration and augmentation of bone using mesenchymal stem cells

Biological material for the repair of connective tissue defects comprising mesenchymal stem cells and hyaluronic acid derivative

An implant for repair of a tissue defect comprises a plurality of physiologically compatible load-bearing sutures for securing under tension tissue adjacent to the defect to be repaired, the sutures for supporting a tissue reparative cell mass in the defect and a tissue reparative cell mass supported thereby. The sutures have a central portion encapsulated in a cell containing matrix which is contracted under a tensile load by the cells thereof and formed into a mat sheet during the contraction. Spring metal wires hold the sutures in tension during the contraction. The matrix is a collagen gel or other material which the cells contract, the cells comprising human mesenchymal stem cells. The mat sheet is then rolled into a spiral roll with the sutures extending from opposite roll ends to form the desired implant. Different embodiments are disclosed.

Biomatrix for soft tissue regeneration using mesenchymal stem cells

A structurally rigid biodegradable foam scaffold useful for cell transplantation is provided. The foam can be loaded with nutrients and/or drugs that elute from the foam during transplant to promote growth of the cells. The foam, which features a continuous network of pores, is fabricated using a novel method involving phase separation and consequent expansion upon sublimation of a liquid solvent, preferably naphthalene.

Biodegradable foams for cell transplantation

Growing community of inventors

Baltimore, MD, United States of America

Sudhakar Kadiyala