Mesoscale Technologies, Llc.

The Henry M. Jackson Foundation for the Advancement of Military Medicine Inc.

Other

Bioveris Corporation

Sudeep Kumar

Eli N Glezer

George B Sigal

Michael Tsionsky

Bandele J Jeffrey-Coker

Sandor L Kovacs

Kenneth E Page

Charles M Clinton

Carl C Stevens

Michael L Vock

Pankaj Oberoi

Kristian Roth

Jeff D Debad

Jeffery D Debad

John H Kenten

Gisbert Spieles

Michael Warnock

Anu Mathew

Natalia I Ossetrova

Sharon West

William F Blakely

Stephen Higgins

Noel Lawrence

Nicholas Anderson

Jeffery Debad

George Sigal

Kenneth Page

Xinri Cong

Jon S Willoughby

Hans Biebuyck

Charles Quentin Davis

Martin Stengelin

Anahit Aghvanyan

Michael Vock

Galina Nikolenko

Josephus Marinus Otten

Srikant Vaithilingam

Eli N Glezar

Bandele Jeffrey-coker

Disclosed are methods for conducting diagnostic tests for the detection of the inflammatory bowel diseases, such as Crohn's disease and ulcerative colitis. Also described are methods for monitoring a patient by administering tests of the present invention. Also described are methods for monitoring patient's treatment by administering tests of the present invention. Also described are methods for evaluating the effectiveness of a drug or a drug candidate by administering tests of the present invention to samples from patients, animal models, and cell cultures treated with a drug or a drug candidate. Also disclosed are methods for determining the usefulness of analytes, e.g. cytokines, for acting as diagnostic and monitoring markers for inflammatory bowel disease in the various methods of the invention.

Methods for diagnosing an inflammatory bowel disease based on soluble tumor necrosis factor II (sTNFRII) levels in a patient sample and treating thereafter

We describe apparatuses, systems, method, reagents, and kits for conducting assays as well as process for their preparation. They are particularly well suited for conducting automated sampling, sample preparation, and analysis in a multi-well plate assay format. For example, they may be used for automated analysis of particulates in air and/or liquid samples derived therefrom in environmental monitoring.

Assay apparatuses, methods and reagents

The invention relates to methods for conducting binding assays in an assay device that includes one or more storage and use zone. The storage zones of the assay device are configured to house one or more reagents used in an assay conducted in the use zone of the device.

Reagent storage in an assay device

Assay cartridges are described that have a plurality of chambers and a fluidic network that includes fluidic conduits and a multi-port valve designed to selectively connect the valve inlet and one valve outlet through a fluidic connector in the valve as the remaining valve outlets are sealed.

Assay cartridge valve system

Assay cartridges are described that have a detection chamber, preferably having integrated electrodes, and other fluidic components which may include sample chambers, waste chambers, conduits, vents, bubble traps, reagent chambers, dry reagent pill zones and the like. In certain embodiments, these cartridges are adapted to receive and analyze a sample collected on an applicator stick. Also described are kits including such cartridges and a cartridge reader configured to analyze an assay conducted using an assay cartridge.

Assay cartridges and methods of using the same

Methods and kits to assess an absorbed dose of ionizing radiation and/or the severity of tissue injury from radiation in a patient. Also, algorithms used to calculate an absorbed dose of radiation based on biomarker measurements of a plurality of biomarkers that are altered relative to a normal control in the event of radiation exposure.

Biodosimetry panels and methods

The invention relates to methods for conducting solid-phase binding assays. One example is an assay method having improved analyte specificity where specificity is limited by the presence of non-specific binding interactions.

Methods for conducting multiplexed assays

Assay cartridges are described that have purification, reaction, and detection zones and other fluidic components which can include sample chambers, waste chambers, conduits, vents, reagent chambers, reconstitution chambers and the like. The assay cartridges are used to conduct multiplexed nucleic acid measurements. Also described are kits including such cartridges, methods of using the same, and a reader configured to analyze an assay conducted using an assay cartridge.

The present invention relates to methods of diagnosing lung cancer in a patient, as well as methods of monitoring the progression of lung cancer and/or methods of monitoring a treatment protocol of a therapeutic agent or a therapeutic regimen. The invention also relates to assay methods used in connection with the diagnostic methods described herein.

Lung cancer biomarkers

The present invention relates to methods and kits to assess an absorbed dose of ionizing radiation and/or the severity of tissue injury from radiation in a patient. The invention also relates to algorithms used to calculate an absorbed dose of radiation based on biomarker measurements of a plurality of biomarkers that are altered relative to a normal control in the event of radiation exposure.

The present invention relates to methods, devices and systems for associating assay information with an assay consumable used in a biological assay. Provided are assay systems and associated consumables, wherein the assay system includes a reader adapted to read/erase/write information from/to an assay consumable identifier associated with the assay consumable. Various types of assay information are described, as well as methods of using such information in the conduct of an assay by an assay system.

Assay information management methods and devices

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Gaithersburg, MD, United States of America

Sudeep Kumar