National Institute of Biological Sciences, Beijing

Sudan He

Xiaoguang Lei

Xiaodong Wang

Zhiyuan Zhang

Yaning Su

Hanying Ruan

Liming Sun

Chao Li

Ting Dong

The invention provides amides that inhibit cellular necrosis and/or human receptor interacting protein 1 kinase (RIP1), including corresponding sulfonamides, and pharmaceutically acceptable salts, hydrates and stereoisomers thereof. The compounds are employed in pharmaceutical compositions, and methods of making and use, including treating a person in need thereof with an effective amount of the compound or composition, and detecting a resultant improvement in the person's health or condition.

Necrosis inhibitors

The invention provides amides that inhibit cellular necrosis and/or human receptor interacting protein 1 kinase (RIP1), including corresponding sulfonamides, and pharmaceutically acceptable salts, hydrides and stereoisomers thereof. The compounds are employed in pharmaceutical compositions, and methods of making and use, including treating a person in need thereof with an effective amount of the compound or composition, and detecting a resultant improvement in the person's health or condition.

The invention provides novel compounds and compositions for inhibiting IKK&#x3b1;/&#x3b2;, including treating disorders associated with IKK&#x3b1;/&#x3b2; activity, including cancer, autoimmune and inflammatory disorders, with a compound of structure: 

Sesquiterpenoids

Growing community of inventors

Beijing, China

Sudan He