Janssen Pharmaceutica Nv

Senhwa Biosciences, Inc.

Rapport Therapeutics, Inc.

Suchitra Ravula

Michael K Ameriks

Brian Ngo Laforteza

Wei Zhang

Gang Chen

Devin M Swanson

Bradley M Savall

Brock T Shireman

Terry Patrick Lebold

Chaofeng Huang

Mustapha Haddach

Brad M Savall

Fabrice Pierre

Dongpei Wu

Nicholas Brian Raffaele

Joe Anh Tran

David M Ryckman

Collin F Regan

Cynthia G B Berry

Warren Stanfield Wade

Brice M Stenne

Jeannie M Ziff

Stephen Todd Meyer

Márió Gyuris

János Gerencsér

Emma Helen Southgate

Jamie M Schiffer

Miguel Angel Pena Piñon

David Wei Lin

Fabrice Loic Jourdan

Joe A Tran

Nicholas B Raffaele

Miguel Angel Pena PIÑÓN

Cynthia GB Berry

Provided herein are compounds of Formula (I), and pharmaceutically acceptable salts, N-oxides, or solvates thereof, Also provided herein are pharmaceutical compositions comprising compounds of Formula (I) and methods of using compounds of Formula (I).

Azabenzimidazoles and their use as AMPA receptor modulators

Bridged compounds of Formula (I) and Formula (II), pharmaceutical compositions containing them, methods of making them, and methods of using them including methods for treating disease states, disorders, and conditions associated with MGL modulation, such as those associated with pain, psychiatric disorders, neurological disorders (including, but not limited to major depressive disorder, treatment resistant depression, anxious depression, bipolar disorder), cancers and eye conditions. wherein R, RR, Rand Rare defined herein.

Monoacylglycerol lipase modulators

Fused and bridged compounds of Formula (I), and pharmaceutically acceptable salts, isotopes, N-oxides, solvates, and stereoisomers thereof, pharmaceutical compositions containing them, methods of making them, and methods of using them including methods for treating disease states, disorders, and conditions associated with MGL modulation, such as those associated with pain, psychiatric disorders, neurological disorders (including, but not limited to major depressive disorder, treatment resistant depression, anxious depression, autism spectrum disorders, Asperger syndrome, bipolar disorder), cancers and eye conditions: wherein R, R, R, and R, are defined herein.

Fused compounds of Formula (I) and Formula (II), pharmaceutical compositions containing them, methods of making them, and methods of using them including methods for treating disease states, disorders, and conditions associated with MGL modulation, such as those associated with pain, psychiatric disorders, neurological disorders (including, but not limited to major depressive disorder, treatment resistant depression, anxious depression, bipolar disorder), cancers and eye conditions. Wherein R, R, R, R, R, R, and Rare defined herein.

Provided herein are compounds of Formula (I), and pharmaceutically acceptable salts, N-oxides, or solvates thereof,  Also provided herein are pharmaceutical compositions comprising compounds of Formula (I) and methods of using compounds of Formula (I).

Benzimidazolone and benzothiazolone compounds and their use as AMPA receptor modulators

Provided herein are compounds of Formula (I), and pharmaceutically acceptable salts, N-oxides, or solvates thereof, Also provided herein are pharmaceutical compositions, comprising compounds of Formula (I), and methods of using compounds of Formula (I).

Indolone compounds and their use as AMPA receptor modulators

Fused azaheterocyclic compounds and their use as AMPA receptor modulators

Fused bicylic pyridine compounds and their use as AMPA receptor modulators

The invention provides compounds that inhibit protein kinase CK2 activity (CK2 activity), and compositions containing such compounds. These compounds and compositions are useful for treating proliferative disorders such as cancer, as well as other kinase-associated conditions including inflammation, pain, and certain immunological disorders, and have the following general formula: 

Pyrazolopyrimidines and related heterocycles as CK2 inhibitors

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San Diego, CA, United States of America

Suchitra Ravula