Gharda Chemicals Limited

Suchet Saran Mathur

Keki Hormusji Gharda

Shekhar Vishwanath Sathe

Pragnesh Dalpatram Damania

Pulinattu Cherian Joseph

Mathew Abraham

Ashokkumar Maganlal Malte

Deepak R Naladkar

Rahul Harishchandra Khamkar

A Kalirajan

Prashant Arun Deshmukh

Mahesh Vishwas Pawar

Janardan K Nambodari

Sanjay C Limaye

Nandkumar Janardan Jain

Kailas Ambadas Chavan

Keki Horsmusji Gharda

Abraham Mathew

Shekhar V Sathe

KA Chavan

Ashokkumar M Malte

PC Joseph

The present disclosure relates to a process for the preparation of pyrazole-oxadiazepine. The process of the present disclosure reduces solvent use, uses inexpensive and easily available reagents. The process is simple, efficient, environment friendly, and provides pyrazole-oxadiazepine with high purity and high yield.

Process for the preparation of pyrazole-oxadiazepine

The present disclosure relates to a process for synthesis of mesotrione. The process comprises reacting 4-toluene sulfonyl chloride with alkali metal sulphite and alkali metal bicarbonate to obtain alkali metal toluene-4-sulfinate. The alkali metal toluene-4-sulfinate is reacted with alkali metal salt of monochloroacetic acid to obtain 4-methylsulfonyl toluene. Further, 4-methylsulfonyl toluene is nitrated to obtain 2-nitro-4-methylsulfonyl toluene. 2-nitro-4-methylsulfonyl toluene is oxidized and then halogenated to obtain 2-nitro-4-methylsulfonylbenzoyl halide. 2-nitro-4-methylsulfonylbenzoyl halide is reacted with alkali metal salt of 1,3-cyclohexanedione to obtain 3-(2-Nitro-4-methylsulfonylbenzoyloxy)cyclohexen-1-one which is reacted with base, a third fluid medium and cyanide ion source to obtain an amorphous mesotrione. The present disclosure also discloses the steps of converting the amorphous mesotrione to crystalline mesotrione having purity greater than 99%. The process of the present disclosure for preparing mesotrione is rapid, economic, and environment friendly.

Process for synthesis of mesotrione

A process for the preparation of an alkali metal salt of 4-chloro-4'-hydroxy benzophenone including the steps of (a) preparing purified 4-chloro-4&#x2032;-hydroxy benzophenone by a process including distilling under reduced pressure a liquid containing 4-chloro-4&#x2032;-hydroxy benzophenone and a solvent selected from diphenyl sulphone, diphenylene sulphone, benzophenone and dichlorobenzophenone, and then (b) preparing the alkali metal salt of thus purified 4-chloro-4&#x2032;-hydroxy benzophenone by the reaction of the purified 4-chloro-4&#x2032;-hydroxy benzophenone with a stoichiometric excess of at least one alkali metal base. There is also described a polymerization process using the alkali metal salt to yield PEK with high inherent viscosity and improved mechanical and thermal properties.

Polyether ketone, its monomer and its phenolate

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Maharashtra, India

Suchet Saran Mathur