Bristol-Myers Squibb Compnay

Subramanya Hegde

Alaric J Dyckman

Sreekantha Ratna Kumar

Laxman Pasunoori

Christopher P Mussari

Dharmpal S Dodd

Trevor C Sherwood

Shoshana L Posy

Tasir Shamsul Haque

Brian K Whiteley

Anupama Kandhi Ramachandra Reddy

Rushith Kumar Anumula

John E Macor

Louis John Lombardo

Ramesh Kumar Sistla

John L Gilmore

Srinivasan Kunchithapatham Duraisamy

Pitani Veera Venkata Srinivas

David R Tortolani

Michael A Poss

Durga Buchi Raju Barre

Vikram Bhogadi

Tasir Shamsul Hague

Anupame Kandhi Ramachandra Reddy

Srinivasan Kunchithaptham Duraisamy

Disclosed are compounds of Formula (I) N-oxides, or salts thereof, wherein X, Y, A, G, R, and Rare defined herein. Also disclosed are methods of using such compounds as inhibitors of signaling through Toll-like receptor 7, or 8, or 9, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating inflammatory and autoimmune diseases.

Substituted bicyclic heteroaryl compounds

Disclosed are compounds of Formula (I) N-oxides, or salts thereof, wherein G, A, R, and n are defined herein. Also disclosed are methods of using such compounds as inhibitors of signaling through Toll-like receptor 7, or 8, or 9, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating inflammatory and autoimmune diseases.

Substituted benzimidazolone compounds

Disclosed are compounds of Formula (I) or a salt thereof, wherein R, R, R, R, R, m, n, and p are defined herein. Also disclosed are methods of using such compounds as inhibitors of signaling through Toll-like receptor 7, or 8, or 9, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating inflammatory and autoimmune diseases.

[1,2,4]triazolo[1,5-a]pyridinyl substituted indole compounds

Disclosed are compounds of Formula (I) N-oxides, or salts thereof, wherein G, A, R, R, and n are defined herein. Also disclosed are methods of using such compounds as inhibitors of signaling through Toll-like receptor 7, or 8, or 9, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating inflammatory and autoimmune diseases.

Substituted indole compounds useful as TLR inhibitors

4-azaindole compounds

Disclosed are compounds of Formula (I) or salts thereof, wherein Ring Het, R, R, R, R, R, m, n, and p are defined herein. Also disclosed are methods of using such compounds as inhibitors of signaling through Toll-like receptor 7, or 8, or 9, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating inflammatory and autoimmune diseases.

Substituted indole compounds

N-oxides, or salts thereof, wherein G, L, R, R, R, R, and n are defined herein. Also disclosed are methods of using such compounds as inhibitors of signaling through Toll-like receptor 7, or 8, or 9, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating inflammatory and autoimmune diseases. 

Amide substituted indole compounds useful as TLR inhibitors

Disclosed are compounds of Formula (I) or salts thereof, wherein A, G, R1, R5, and n are defined herein. Also disclosed are methods of using such compounds as inhibitors of signaling through Toll-like receptor 7, or 8, or 9, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating inflammatory and autoimmune diseases. 

Aryl and heteroaryl substituted indole compounds

[1,2,4]triazolo[1,5-A]pyridinyl substituted indole compounds

4-Azaindole compounds

Disclosed are compounds of Formula (I) N-oxide, or salt thereof, wherein R, R, R, R, R, m, n, and p are defined herein. Also disclosed are methods of using such compounds as inhibitors of signaling through Toll-like receptor 7, or 8, or 9, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating inflammatory and autoimmune diseases. 

Pyridyl substituted indole compounds

Growing community of inventors

Bengaluru, India

Subramanya Hegde