Vanderbilt University

Calyx Therapeutics, Inc.

Anergen, Inc.

Natpro, Inc.

Subramaniam Sriram

Bishwajit Nag

Somesh D Sharma

William M Mitchell

Charles W Stratton

John Bright

Methods for stimulating neural repair and remyelination and for treating a myelin related disorder in a subject are described. The methods include administering to a subject in need of treatment an effective amount of anacardic acid having the formula (I) of claimor a pharmaceutically acceptable salt thereof.

Anacardic acid for neural repair

The invention features methods and reagents for the diagnosis, monitoring, and treatment of multiple sclerosis. The invention is based in part on the discovery thatis present in patients with multiple sclerosis, and that anti-chlamydial agents improve or sustain neurological function in these patients.

Methods and reagents for the treatment of multiple sclerosis

The invention features methods and reagents for the diagnosis, monitoring, and treatment of multiple sclerosis. The invention is based in part on the discovery that Chlamydia is present in patients with multiple sclerosis, and that anti-chlamydial agents improve or sustain neurological function in these patients.

Methods and treatment of multiple sclerosis

Protein kinase inhibitor

Disclosed herein are compounds of the formula I

The present invention provides immunogenic oligopeptides derived from the Major Histocompatibility Complex (MHC) glycoprotein protein sequences for use in compositions and methods for the treatment, prevention and diagnosis of deleterious immune responses, such as autoimmunity and allergies. The peptides are capable of inducing an immune response against glycoproteins encoded MHC alleles associated with the target disease. In preferred embodiments the peptides of the invention are derived from hypervariable region of the .beta. chain of an MHC Class II molecule associated with the deleterious immune response.

Vaccination with peptide of MHC class II molecules for treatment of

A compound of the formula I ##STR1## wherein A and C are independently H, alkyl of 1-6 carbon atoms, hydroxy, or alkoxy of 1-6 carbon atoms;

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Nashville, TN, United States of America

Subramaniam Sriram