Warner-lambert Company

Fuisz Technologies Ltd.

Capricorn Pharma, Inc.

Other

Jsr Corporation

Biovail Technologies Ltd.

Fuisz International Ltd.

Werner-lambert Company

Subraman R Cherukuri

Gul Mansukhani

Steven M Faust

Lucy L Wong

Krishna P Raman

Gerald E Battist

Richard C Fuisz

Jose F Zamudio-Tena

Robert K Yang

Frank T Hriscisce

Angel M Orama

Tommy L Chau

Kenneth P Bilka

You C Wei

Garry L Myers

Daniel A Orlandi

James H Perkins

Michael Glass

Albert E Siecke

Andrea S Blake

Supapong Siris

Kapakkamannil C Jacob

Kirshna P Raman

Martin K Schaller

Santi R Bhowmik

Cecil A Bowles

Matthew J Strait

Suresh B Kota

Paul M Croushorn

James A Duggan

Saul M Shiffman

Mamoun M Hussein

Pradeepkumar P Sanghvi

Shirley A Barcelon

Tushar K Misra

Claude Bayard

Martin M Rieger

Dominic J Piccolo

Jack E Henningfield

Edward J Cone

John R Sisak

John M Pinney

Alfred Oppenheimer

Ralph Cifrese

Michael J Killeen

Frank P Calabro

Peter King

T Victor Oh

Francisco Zamudio-Tena

Milton Elefant

J Francisco Zamudio-Tena

Carlos D Malvestutto

Joe Gitchell

Aradhana Sasan

David M Teale

Tommy K Chau

Elnoria Tolliver

Abhijit Banerjee

Amrik L Khurana

Bei Zhang

James L Stewart

Sambasiva Ghanta

Ellen Marschall-Helman

Amrik Khurana

Kirshnayya Bikkina

The present invention is directed to multi-layered compositions for oral administration having at least one orally disintegrating layer and capable of maintaining layer cohesion. The present invention is also directed to methods of manufacturing such compositions.

Orally disintegrating layered compositions

A novel rapid-melt, semi-solid molded composition, including methods of making the same, and methods of using the same for the delivery of prophylactic and therapeutic active materials to a mammal wherein the prophylactic or therapeutic active is a psychotropic, a gastrointestinal therapeutic or a migraine therapeutic.

Rapid-melt semi-solid compositions, methods of making same and methods of using same

A novel encapsulated product is provided and includes: at least one active ingredient; at least one compressible material; and at least one tableting material; wherein the encapsulated product is in the form of a caplet having a diameter of from about 1 millimeter to about 7 millimeters and a length from about 1 millimeter to about 7 millimeters. A method for preparing the encapsulated product is also provided. The encapsulated product may be incorporated into a food item, a confectionery product or chewing gum product.

Alternate encapsulation process and products produced therefrom

A method of producing a chewy confectionery involves high or low shear mixing with no cooking to produce a mass which is well hydrated and yet has no phase separation of moisture. A bioaffecting agent included in the confectionery is effectively taste-masked, even one that is typically organoleptically unpalatable.

Positive hydration method of preparing confectionery and product therefrom

A novel rapid-melt, semi-solid molded composition including at least one binder in an amount from about 0.01% to about 70% by weight; a salivating agent in an amount from about 0.05% to about 15% by weight, a diluent/bulking material in an amount from about 10% to about 90% by weight; and an active material in an amount from about 0.001% to about 70% by weight. Further, the inventive subject matter includes a method of preparing a rapid-melt, semi-solid molded composition comprising the steps of: melting at least one binder in an amount from about 0.01% to about 70% by weight with a salivating agent in an amount from about 0.05% to about 15% by weight, to form a mixture; mixing an active material with said mixture to form an active mixture; mixing a diluent/bulking material with said active mixture to form a final mixture; and molding said final mixture into said semi-solid molded composition.

Rapid-melt semi-solid compositions, methods of making same and method of using same

A novel encapsulated product is provided and includes: at least one active ingredient; at least one compressible material; and at least one tableting material; wherein the encapsulated product is in the form of a caplet having a diameter of from about 1 millimeter to about 7 millimeters and a length from about 1 millimeter to about 7 millimeters. A method for preparing the encapsulated product is also provided. The encapsulated product may be incorporated into a food item, a soft confectionery product, a hard confectionery product, a jelly gum confectionery product, and a dry beverage or chewing gum product.

Confectionery compositions and methods of making

A chewing gum delivery system has nicotine, gum base and a buffer system with an improved release rate for the nicotine. The resulting delivery system advantageously provides a convenient, reliable, practical, and relatively painless system for delivering an active. The delivery system is capable of delivering initial and second doses of a craving reduction active or other actives (e.g., nicotine), the combination of which rapidly reduces cravings, or provides some other pharmacological effect, and provides the pharmacological effect or protection from such cravings over a prolonged period of time beyond the initial dose. Notably, the delivery system is capable of rapidly achieving a pharmacologically effective concentration of the active (e.g., nicotine) in the bloodstream (e.g., within 5 minutes, or more desirably within 3 minutes, or in some cases, within 1-2 minutes), and is also capable of keeping the concentration of the active in the bloodstream at or near the pharmacologically effective concentration for at least 20 minutes after chewing of the delivery system begins, or more desirably about 30 minutes to about 50 minutes after chewing begins.

Medicated chewing gum delivery system for nicotine

A method and apparatus provides for the formation of an encapsulated feedstock product matrix. A solid product matrix additive is spray ejected in a free-flow condition. The matrix additive is encapsulated in its free-flow condition with a matrix encapsulant. The encapsulant additive substantially solidifies in its free-flow condition to form the feedstock product matrix.

Method and apparatus for forming an encapsulated product matrix

A chewing gum composition for instant and extended release breath freshening has a gum base, at least one wetting agent, at least one immediate release flavor ingredient, and at least on encapsulation. The encapsulations include flavor encapsulations, metallic ion encapsulations, and organic substance encapsulations.

Breath Freshening chewing gum with encapsulations

The present invention is a new mesomorphic polycrystallite product and a process for making the same. In the present invention amorphous sugar is transformed to a mesomorphic product having polycrystallites therein by a completely anhydrous process rather than by hydrating and then dehydrating the sugar. The product of the present invention is unique in shape and size, and possesses a high degree of uniformity. The properties of the polycrystallite make it possible to replace some or all of the fat in comestibles such as frostings and fillings and to provide fondants of extraordinarily fine grain.

Method of preparing mesomorphic sugar products

A beverage composition has a source of fiber, as well as one or more additional nutrients. The composition is in the form of a shearform matrix as a result of flash-flow processing. The beverage composition is highly storage stable.

Fiber and vitamin-fortified drink composition and beverage and method of

A composition and method for preparing multi-vitamin comestible units which disperse quickly in the mouth, especially when chewed, includes initiating crystallization of shearform matrix with crystallization/binding promoter and combining with an additive to form flowable, compactible micro-particulates. The combination is then shaped to form a comestible unit having high structural integrity, good appearance, and excellent release characteristics.

Process for forming chewable quickly dispersing multi-vitamin

The present invention deals with compositions and methods for preparing comestible units which disperse quickly in the mouth, especially when chewed. The present invention also includes the product made therefrom. The method includes initiating crystallization of shearform matrix with crystallization/bindig promoter and combining it with an additive to form flowable, compactible micro-particulates. The combination is then shaped to form a comestible unit having high structural integrity, good appearance, and excellent release characteristics.

Process for forming chewable quickly dispersing comestible unit and

The present invention is a method of preparing a comestible unit which disperses quickly in the mouth. The present invention also includes the product resulting from the method. The method includes initiating crystallization of shearform matrix and combining with an additive, either before or after initiating crystallization, to form flowable, compactible micro-particulates. The combination is then subjected to compacting to form a comestible unit having high structural integrity, good appearance, and excellent release characteristics.

Process for forming quickly dispersing comestible unit and product

Growing community of inventors

Towaco, NJ, United States of America

Subraman R Cherukuri