Mallinckrodt, Inc.

Humanwell Pharmaceutical US

Pharmacia Corporation

Yichang Humanwell Pharmaceuticals Co. Ltd.

Specgx LLC

Subo Liao

Peter Xianqi Wang

David W Berberich

Tao Jiang

Bobby N Trawick

Gary Lee Cantrell

Jun Yang

John Brandt

Gunnar J Hanson

Michael L Vazquez

Michael John Clare

Richard M Weier

Richard A Partis

Timothy J Hagen

Michael B Tollefson

Suzanne S Metz

Michael A Stealey

Francis J Koszyk

Patrick J Lennon

Bruce C Hamper

He Huang

Xiangdong Xu

Arija A Bergmanis

Lifeng Geng

Shuyuan Liao

Joyce Zuowu Crich

Thomas Dale Owen

Stephen C Houdek

Joseph P McClurg

Dominique Bonafoux

Scott B Mohler

Donna M Iula

Theresa R Fletcher

Serge G Wolfson

Jinliang Lv

Zongquan Liao

Hao Zhou

Maria Nguyen

David S Oburn

Tianpeng Xie

Angela M Scates

Jueyuan Gao

Quanli Yang

Christopher W Grote

Frank William Moser

Esa T Jarvi

Lei Wang

Edmund C Hudson

Douglas C Miller

Hang Sun

Doug Teramura

Jie Li

Jianbo Yu

Michael Schaefer

Wentao Du

Erin Moore

Todd Osiek

Lie Li

Zejian Ding

Bobby Trawick

Joseph Mcclurg

Joseph P Mcclurg

The present invention provides kappa opioid receptor peptide agonists, methods for preparing these compounds, compositions comprising these kappa opioid receptor peptide agonists, and methods of using the kappa opioid receptor peptide agonists to treat pain or other conditions.

Kappa opioid receptor peptide amide ligands

The present invention provides compounds which are selective kappa-opioid receptor agonist, method of preparation of these compounds, compositions that comprise these compounds, and methods for treating kappa-opiod receptor agonist related medical disorders.

Peptides for treatment of medical disorders

The present invention related to novel morphinans, compositions comprising the novel morphinans, and their uses as agonists of the kappa opioid receptor.

Morphinans useful for treating medical disorders

Processes for preparing 3-substituted phenylalkylamines comprising reacting a phenyl boronic compound with an &#x3b1;-&#x3b2; unsaturated carbonyl-containing compound via an asymmetric 1,4-addition reaction, followed by reductive alkylation. The processes may be useful in the synthesis of tapentadol.

Two-step process for preparing 3-substituted phenylalkylamines

The invention provides methods for preparing substituted phenylalkanes. In particular, the processes comprise reacting a phenyl boronic compound with an &#x3b1;-&#x3b2; unsaturated carbonyl-containing compound via an asymmetric 1,4-addition reaction. The processes may be useful in the synthesis of tapentadol.

Process for preparing substituted phenylalkanes

The present invention provides processes for preparing normorphinans from N-substituted morphinans. In particular, the invention provides methods for removing the N-substituent from the N-substituted morphinan to from a normorphinan carbamate, and then removing the carbamate functionality from the normorphinan carbamate to form the normorphinan.

Preparation of normorphinans

The present invention provides processes for the preparation of N-alkyl morphinans without the isolation of nor-morphinan intermediates. In particular, the invention provides tandem hydrolysis/alkylation reactions for the synthesis of N-alkyl morphinans.

Tandem process for preparing N-alkyl morphinans

The present invention provides processes for the demethylation of an N-methyl morphinan comprising a ketone functional group. In particular, the invention provides methods for the protection of the ketone functional group such that impurities are not generated during the demethylation of the N-methyl morphinan.

N-demethylation of 6-keto morphinans

The invention generally provides processes and intermediate compounds useful for the production of sinomenine derivatives. In particular, the process may encompass synthetic routes for the production of (+)-sinomenine derivatives and their intermediates.

Sinomenine derivatives and processes for their synthesis

The present invention provides (+)-morphinanium N-oxide compounds or pharmaceutically acceptable salts thereof. The invention also provides processes for producing (+)-morphinanium N-oxides or pharmaceutically acceptable salts thereof from the corresponding tertiary N-substituted (+)-morphinan compound or pharmaceutically acceptable salt thereof.

(+)-morphinanium N-oxides and processes for their production

The present disclosure generally relates to a process for converting a fused, tricyclic compound to a fused, tetracyclic compound that includes a furan ring therein. More particularly, the present disclosure related to a process for preparing a hydrocodone compound, or a compound structurally related thereto, and in particular (+)-hydrocodone, by subjecting a structurally corresponding sinomenine starting compound to a super acid-assisted furan ring closure reaction.

Process for preparing hydrocodone using a super acid

The invention generally provides processes and intermediate compounds useful for the production of (+)-opiates. Non-limiting examples of (+) opiates that may be derived from one or more compounds of the invention include (+)-noroxymorphone, (+)-naltrexone, (+)-naloxone, (+)-N-cyclopropylmethylnorhydrocodone, (+)-N-cycloproylmethylnorhydromorphone, (+)-N-allylnorhydrocodone, (+)-N-allylnorhydromorphone, (+)-noroxycodone, (+)-naltrexol, (+)-naloxol, and (+)-3-O-methyl-naltrexone.

Process and compounds for the production of (+)opiates

The invention generally provides processes and intermediate compounds useful for the production of (+) nal morphinan compounds. In particular, the process encompasses synthetic routes for the production of (+) nal morphinan compounds or derivatives of (+) nal morphinan compounds from (+)-morphinan substrates such as (+)-hydrocodone, (+)-norhydrocodone or derivatives of either compound.

Processes for the production of (+)- 'Nal' morphinan compounds

The invention generally provides processes for the production of buprenophine and derivatives of buprenorphine. In particular, the process may encompass synthetic routes for the production of buprenorphine or derivatives of buprenorphine from norhydromorphone or derivatives of norhydromorphone.

Process for the preparation of buprenorphine and derivatives for buprenorphine

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Ballwin, MO, United States of America

Subo Liao