Council of Scientific and Industrial Research

Fdc Limited

Subhash Prataprao Chavan

Uttam Ramrao Kalkote

Mohan Anand Chandavarkar

Hanumant Bapurao Borate

Amit Chandrakant Tawte

Deepali Damodar Rao

Subhash Krishnaji Kamat

Kamalam Balakrishnan

Latha Sivadasan

Mukund Keshao Gurjar

Ravindranathan Thottapillil

Thottappillil Ravindranathan

Sandeep Raghunath Ghorpade

Amar Gopal Chittiboyina

Sunil Ramchandra Bhide

Dushant Anandrao Khobragade

Pradeep Bhaskarrao Lasonkar

Ramkrishnan Ramachandran Iyer

Kailash Pralhad Pawar

Beena Rai

Arumugamangalam Venkataraman Ramaswamy

Thottapillil Ravindranathan

Suleman Riyajsaheb Maujan

Sangmeshwer Prabhakar Sawargave

Alive Keshavaraja

Sunita Sharad Kunte

Gajanan Jalindar Chavan

Rajkumar B Tejwani

Ramkrishnan Ramachaandran Iyer

Sangmeshwer Prabhkara Sawargave

Ananda Shahaji Kudale

Vishnu Hari Deshpande

Ramalingam Sadyandi

Shubhada Wasudeo Dantale

Puduklatan Kadar Zubaidha

Prakash Narsing Chavan

Sangeshwer Prabhakar Sawargave

Ramakrishnan Ramacahndran Iyer

Sumanta Garai

Thotapallil Ravindranathan

Vikas Vasant Nawathye

Hanumat Bapurao Borate

The patent discloses a novel metal free process for the preparation of corresponding phenol and ketone via allylic oxidation of substituted cyclohexenes. Air is used as oxidant in the present process and can be used as such or optionally selected from pure oxygen or atmospheric oxygen. Moreover, the process of the present invention utilizes easily available starting materials and is a green eco-friendly, convenient and economical process with high yield of &#x3e;60% and high selectivity.

Metal free process for allylic oxidation

The present invention provides a process for the synthesis of olopatadine. Further, the invention discloses a process that results in improved yield of the desired Z isomer.

Process for the synthesis of olopatadine

Disclosed herein are novel antifungal compounds of Formula 1, containing 1-substituted, 4-(substituted phenoxy-methyl)-1,2,3-triazole moieties coupled to a core having triazole ring, (un)substituted phenyl ring and tertiary alcoholic functionality, and pharmaceutically acceptable salts thereof; methods for preparing these compounds; and pharmaceutical preparations containing these novel compounds for prevention and treatment of fungal infections. 

1-substituted, 4-(substituted phenoxymethyl)-1,2,3-triazole compounds with antifungal properties and methods for preparation thereof

There is a need for short, resolution free asymmetric process for synthesis of one isomer of venlafaxine, (&#x2212;)-venlafaxine. The invention provides a novel, short process of synthesis of (&#x2212;)-venlafaxine, with yield greater than 50% and ee&#x3e;99%. This process can be used for racemic synthesis of venlafaxine with overall yield 65%.

Process for total synthesis of venlafaxine

The present invention discloses an economic, simple, azide and aziridine complexity free process for the synthesis of osletamivir phosphate (Tamiflu) by stereospecific amidoalkylation of imidazothiazolone from easily available L-cysteine via Ramberg-Backlund reaction and Sharpless-Reich protocol.

Process for the preparation of intermediate for the preparation of oseltamivir phosphate

Disclosed herein are novel antifungal compounds of Formula 1, containing fluconazole pharmacophore moieties coupled with other moieties including aryl enones and chalcones and pharmaceutically acceptable salts thereof, methods for preparing these compounds and pharmaceutical preparations containing these novel compounds for prevention and treatment of fungal infections. 

Hybrid molecules containing pharmacophores of fluconazole as antifungal agents and their preparation

The invention discloses optically active compounds of Formula (1a) or Formula (1b), 

Optically active fluconazole analogues containing thiophenes as antifungal agents

The patent discloses an asymmetric synthesis of (&#x2212;)-venlafaxine using an organocatalyst via a unified strategy employing organcatalytic Michael addition, regio-selective dehydration and selective epoxide ring opening.

Asymmetric synthesis of (&#x2212;)-venlafaxine using organocatalyst

The present invention discloses novel enantiomeric antifungal compounds of Formula (1a) and Formula (1b) containing thieno-[2,3-d]Jpyrimidin-4(3H)-one moiety and pharmaceutically acceptable salts thereof, method of preparing these compounds, the use of these compounds in prevention and treatment of fungal infections, and pharmaceutical preparations containing these compounds. 

Enantiomers of fluconazole analogues containing thieno-[2,-3-D]pyrimidin-4(3H)-one moiety as antifungal agents

Process for the preparation of 1-&lsqb;cyano(aryl)methyl&rsqb; cyclohexanol

A novel route has been developed for substituted 2-&lsqb;-6-benzyl-5-oxo-3-phenyl-(3s,7s,7aR)-perhydroimidazol&lsqb;1,5-c&rsqb;&lsqb;1,3&rsqb;thiazol&rsqb; compounds; crucial intermediates for D(&plus;)-biotin of formula (7) which involves simple, efficient, practical and cost effective protocol. These are crucial intermediates for commercially important D(&plus;)-biotin preparation. These compounds are more stable and are produced by non-hazardous methods.

Substituted 2-&lsqb;-6-benzyl-5-oxo-3-phenyl-(3s,7s, 7aR)-perhydroimidazol&lsqb;1,5-c&rsqb;&lsqb;1,3&rsqb;thiazol-7yl&rsqb; compounds

The present invention relates to a process for the preparation of optically active 6-hydroxymethyl-4-(tert-butyldimethylsilyloxy)-(4R,6S)-tetrahydro-2H-2-pyranone(&bgr;-Hydroxy-&dgr;-lactone) an important intermediate in the synthesis of biologically active drugs e.g. compactin, atorvastatin, fluvastatin, cholesterol lowering drugs.

Process for the preparation of beta hydroxy-delta lactone using novel intermediates

Process for the preparation of &bgr; hydroxy-&dgr; lactone using novel intermediates

A process for the transesterification of keto esters and alcohols in approximately stoichiometric amounts using a solid acid catalyst. Solid acid catalysts may be sulfated zirconia, sulfated tin oxide, sulfated titania, sulfated iron oxide, heteropoly acids, acidic clays, acidic zeolites, or any other solid acids with high acidity or super acidity, with or without dopants. One equivalent or more of keto ester, one equivalent or more of alcohol, the solid acid catalyst, and an appropriate solvent are mixed and heated to 70 to 120&deg; C. at atmospheric or reduced pressure to furnish the keto transester in high yields.

Process for the transesterification of keto esters using solid acids as catalysts

One pot process for the preparation of 1-&lsqb;2-dimethylamino-(4-methoxyphenyl)-ethyl&rsqb;cyclohexanol

Growing community of inventors

Maharashtra, India

Subhash Prataprao Chavan