Kempharm, Inc.

Pharmacia Corporation

Pharmacia Corporation (of Pfizer, Inc.)

Genco Sciences LLC

Subhash Desai

Tugrul T Kararli

Mark Kontny

Michael J Hageman

Randy J Wald

Royal J Haskell

Gary A DeBrincat

Sreekant R Nadkarni

The present invention provides drug therapy formulations for reducing the side effects associated with a therapeutic. In some embodiments, the present invention provides a reduction in sleep- and diet-related side effects associated with a therapeutic.

Therapeutic formulation for reduced drug side effects

The present invention provides drug therapy formulations. In some embodiments, the present invention provides combinations of pharmaceutical agents (e.g., stimulant and non-stimulant), pharmaceutical formulations (e.g., nanoparticualte, non-nanoparticualte, etc.), and release profiles (e g, immediate release, delayed release, sustained release, etc.) to provide therapeutic benefit with reduced side effects.

Compositions for reduction of side effects

Pharmaceutical compositions are provided comprising one or more orally deliverable dose units, each comprising a selective cyclooxygenase-2 inhibitory drug of low water solubility, for example celecoxib, in an immediate-release fraction and a controlled-release, slow-release, programmed-release, timed-release, pulse-release, sustained-release or extended-release fraction. The compositions are useful in treatment or prophylaxis of cyclooxygenase-2 mediated conditions and disorders.

Dual-release compositions of a cyclooxygenase-2 inhibitor

Pharmaceutical compositions are provided comprising one or more orally deliverable dose units, each comprising a selective cyclooxygenase-2 inhibitory drug of low water solubility in a therapeutically effective amount, wherein the drug is present in the form of solid particle, about 25% to 100% by weight of which are smaller than 1 &#x3bc;m. The compositions are useful in treatment or prophylaxis of cyclooxygenase-2 mediated conditions and disorders and have particular advantages where rapid onset of therapeutic effect is desired.

Cyclooxygenase-2 inhibitor compositions having rapid onset of therapeutic effect

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Wilmette, IL, United States of America

Subhash Desai