Glenmark Pharmaceuticals Limited

Subhash Damle

Shekhar Bhaskar Bhirud

Narendra Shriram Joshi

Batchu Chandrasekhar

K Eswara Rao

An improved process for the preparation of pyrimidine derivatives is provided comprising reacting a Wittig reagent of the general formula wherein R is an alkyl of from 1 to 10 carbon atoms, aryl or arylalkyl, Ris a substituted or unsubstituted hydrocarbon group, Rand Rare the same or different and are hydrogen or a substituted or unsubstituted hydrocarbon group; Z is sulfur, oxygen, sulfonyl, or imino which may be substituted by formyl, acetyl, propionyl, butyryl, isobutyryl, valeryl, isovaleryl, amino substituted by sulfonyl or alkylsulfonyl, and sulfonyl substituted by alkyl, amino or alkylamino and X is a halogen; with an aldehyde of the general formula wherein Ris hydrogen, a lower alkyl or a cation capable of forming a non-toxic pharmaceutically acceptable salt and each Rare the same or different and are hydrogen or a hydrolyzable protecting group, or each R, together with the oxygen atom to which each is bonded, form a hydrolyzable cyclic protecting group, or each Ris bonded to the same substituent which is bonded to each oxygen atom to form a hydrolyzable protecting group; in the presence of a base.

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Thane Dist., India

Subhash Damle