Council of Scientific & Industrial Research

Subhash Chandra Taneja

Ghulam Nabi Qazi

Surrinder Koul

Vijay Kumar Sethi

Sukhdev Swami Handa

Vijeshwar Verma

Jawahir Lal Koul

Samar Singh Andotra

Pankaj Gupta

Inshad Ali Khan

Rakesh Kamal Johri

Subhash Chander Sharma

Suresh Chandra

Ashwani Kumar

Ashok Kumar Tikoo

Kanaya Lal Dhar

Ashok Kumar Shahi

Prabhu Dutt

Satya Narayan Sharma

Zahid Mehmood Mirza

Monika Pandita

Anita Khosa

Beenu Moza

Brijesh Kumar

Ajit Kumar Saxena

Bal Krishan Chandan

Bupinder Singh Jaggi

Sanghapal Damodhar Sawant

Ravinder Kumar Raina

Shashank Kumar Singh

Randhir S Kapil

Anil Prabhakar

Mahabalarao Sampath Kumar Halmuthur

Maharaj Krishen Bhan

Maharaj Krishen Kaul

Shazia Zahoor

Surendra Singh Balyan

Swadesh Pal

Ravi Ji Kotru

Rajinder Parshad

A K Saxena

J L Suri

S K Banerjee

A S Anand

Naveed Ahmed Qazi

Abid Zaffar Hashmi

Maharaj Krishan Koul

Sanotosh Kumar Bakshi

Mahendhar Reddy Doma

Abid Hussain Banday

Rattan Lal Sharma

Munish Kapoor

Naveen Anand

Buddh Singh

Surrinder Kaul

Monika Verma

Ghularn Nabi Qazi

Mushtaq Ahmad Aga

The present invention relates to an aromatic substituted pentadienoic acid amides and there use in combination of specific amounts of aromatic amides i.e. 4-alkyl-5-(substituted phenyl)-2 (E),4(E)-pentadienoic acid amides, its geometrical isomers or their dihydro or tetrahydro derivatives and an anti-infective drug useful in potentiating the bioefficacy of antiinfective drug. The combination of the present invention is useful in the treatment of certain infections and disease at lower concentration of anti-infectives necessary to inhibit the growth of microbial strains and may also find applications in reducing the resistance in microorganisms.

Aromatic amides as potentiators of bioefficacy of anti-infective drugs

The present invention relates to novel spiro derivatives of parthenin prepared by the dipolar cycloaddition of various dipoles viz, benzonitrile oxides, nitrones, azides, nitrile ylide diazoalkane, nitrile imide, ozone, azomethine imides, azomethine ylides etc. with exocyclic double bond of C ring (&#x3b1;-methylene-&#x3b3;-butyrolactone). Representative compounds have been screened for their anticancer activity against different cancer cell lines. ICs0 value of these analogues varies between 4.3 &#x3bc;M to 93 &#x3bc;M. A mechanistic correlation of their anticancer activity has been described. The results of the cytotoxicity test of the compounds studies indicated that the &#x3b1;,&#x3b2;-unsaturated ketonic moiety in parthenin plays an important role in the maintenance of the high level of cytotoxicity. 

Spiro derivatives of parthenin as novel anticancer agents

The present invention relates to an aromatic substituted pentadienoic acid amides and there use in combination of specific amounts of aromatic amides i.e. 4-alkyl-5-(substituted phenyl)-2(E),4(E)-pentadienoic acid amides, its geometrical isomers or their dihydro or tetrahydro derivatives and an anti-infective drug useful in potentiating the bioefficacy of antiinfective drug. The combination of the present invention is useful in the treatment of certain infections and disease at lower concentration of anti-infectives necessary to inhibit the growth of microbial strains and may also find applications in reducing the resistance in microorganisms.

The present invention relates to a facile, highly efficient and economical process for the preparation of optically active N-benzyl-3-hydroxypyrrolidine in high yield from a naturally occurring alkaloid vasicine. The natural alkaloid vasicine is used as a precursor of (S)&#x2014;N-benzyl-3-hydroxypyrrolidine and (R)&#x2014;N-benzyl-3-hydroxypyrrolidines which can easily be sourced from the medicinal plant Adatoda vasica by the method known in the art and transformed to optical isomers (R) and (S)&#x2014;N-benzyl-3-hydroxypyrrolidine by the method described in the present invention.

Process for the preparation of optically active N-benzyl-3 hydroxypyrrolidines

The present invention relates to novel compounds possessing specific hot, pungent and spicy taste when subjected to direct pungency evaluation, which may be useful as food additives and anti-oxidants, however the said compounds do not add to any nutritional value but the synthesised compounds can possess useful pharmacological properties which is expected to find application in new test models for the development of anti-inflammatory drugs, bioavailability enhancers and for the study of hepatic drug metabolising mechanism; also relates to a process for preparing the said compounds.

Substituted aryl alkenoic acid heterocyclic amides

The present invention relates to a process for the synthesis of racemic nerol oxide i.e. 3,6-dihydro-4-methyl-2-[2-methyl-1-propenyl)-2H-pyran from monoterpene alcohol nerol i.e. cis-3,7-dimethylocta-2,6-diene-1-ol.

Process for preparation of nerol oxide

The present invention relates to a novel synthetic process for the enriched preparation of substituted R(+)&#x3b2;-benzyl-&#x3b3;-butyrolactone (1) as shown in the drawing wherein Rand Rindependently or in combination represent the following groups: i.e. R&#x2550;R&#x2550;H, &#x2014;OCH(where n=1 to 8); R, and Rtogether represents &#x2014;O(CH)O&#x2014; (where m=2 to 4) 

Chemo-enzymatic process for the preparation of opticaly enriched &#x3b2;-benzyl-&#x3b3;-butyrolactones

The present invention relates to a novel and efficient chemoenzymatic process of preparation of optically active trans alkyl phenylglycidates. The invention particularly discloses a novel process for the chemoenzymatic synthesis of two enantiomers of trans alkyl phenylglycidate i.e. alkyl(2S,3R)-phenylglycidate and alkyl(2R,3S)-phenylglycidate of formulae 7 and 8 respectively 

Stereoselective chemoenzymatic process for the preparation of optically enriched phenylglycidates as precursors of taxol side chain

A new and distinct variety ofgrass is provided. The new variety was discovered during a mass selection program that was carried out in India in a cultivated area, and offers significant advantages over a typical plant of the species. More specifically, the new variety exhibits superior drought tolerance, a vigorous perennial growth habit, and lighter green leaves than typically exhibited by the species. The plant produces an essential oil having an enhanced geraniol and geranyl acetate content that is useful to form perfumes and in flavor applications. Asexual reproduction can be readily carried out by the rooting of slips.

Cymbopogon plant named 'RLJCC1'

The present invention relates to anti-microbial activity of the essential oil of (Nees ex Steud) Wats and the process of isolation of novel sesquiterpene compound which is mainly responsible for the strong anti-microbial/anti-bacterial activity. The present invention particularly relates to anti-bacterial activity of the essential oil and a pure isolate identified as (&plus;)-1-bisabolone of formula 1 against gram positive bacteria from a strain of a grass identified as

(&plus;)-1-Bisabolone isolated from cymbopogon flexuosus and antibacterial activity thereof

The present invention provides a synergistic composition of bioactive fraction essentially constituting iridoid glucosides, acetyl barlerin and shanzhiside methyl ester isolated from a plant source along with a process for the isolation of the bioactive fraction, the present invention also relates to a method of treating mammals and humans for hepatotoxicity, stress and immuno-deficiency with the synergistic bioactive composition.

Synergistic composition of bioactive fraction isolated from barleria prionitis linn and a method of treatment for hepatotoxicity, immuno-deficiency and fatigue and a process thereof

This invention discloses a process for the use of a novel organism belonging to the genus Trichosporon sp. as whole wet or dry cell culture or cell free extract or crude enzyme or pure isolated enzyme The strain of Trichosporon sp. used in the process is designated as RRLY-15 and has been deposited in Deutsche Sammlung von Mikroorganismen und Zellekulturen GmbH (DSMZ). The invention also discloses the preparation of S(&plus;)-6-methoxy-2-naphthalene acetic acid (naproxen) of formula (2) through enantioselective hydrolysis of a racemic mixture of alkyl esters of (&plusmn;)-6-methoxy-&agr;-methyl-2-naphthalene acetic acid of formula (1) where R represents &mdash;CH,,&mdash;C,H,,&mdash;C,H,,&mdash;C,H,and the like and S(&plus;)- Naproxen is a medicinally important non steroidal anti-inflammatory drug.

Trichosporon sp RRLY-15 (DSM 11829) and its use to prepare S(&plus;)-6-methoxy-methyl-2-naphthalene acetic acid

Disclosed herein is a novel fraction comprising a mixture of boswellic acids, wherein the fraction exhibits anti-inflammatory and antiulcerogenic activities. Also disclosed is a novel boswellic acid compound exhibiting anti-inflammatory, antiathritic and antiulcerogenic activities. Also disclosed is a process for isolating a boswellic acid fraction and individual boswellic acids therefrom.

Boswellic acid compositions and preparation thereof

Growing community of inventors

Jammu, India

Subhash Chandra Taneja