Council of Scientific and Industrial Research

Subhash Chandra Singh

Sushil Kumar

Suman Preet Singh Khanuja

Ajit Kumar Shasany

Mahendra Pandurang Darokar

Madan Mohan Gupta

Tiruppadiripuliyur Ranganathan Santha Kumar

Dharmendra Saikia

Anil Kumar Gupta

Ram Kishor Verma

Santosh Kumar Srivastava

Jai Shankar Arya

Arun Kumar Tripathy

Sarita Satapathy

Anirban Pal

Merajuddin Khan

Chandeshwar Nath

Abhay Sharma

Digvijay Singh

Janardan Singh

Subash Chandra Verma

Amaresh Pandey

Raghavendra Kumar Mishra

Anupam Maurya

Dnyaneshwar Umrao Bawankule

Shikha Gupta

Vinay Kumar Khanna

Ashok Kumar Agrawal

The present invention relates to bioactive extracts its fractions and isolation of compound from. The extracts and fractions are useful for the treatment of psychosis based on in-vivo validation on animal model and proportional binding affinities for dopaminergic-D, Cholinergic (muscarinic) and Serotonergic (5HT) receptors for antipsychotic activity. The present invention relates to novel antipsychotic activity in the leaf alkaloids of Formula 1 and 2 named tetrahydroalstonine, 10-methoxytetrahydroalstonine, isoreserpiline, 10-demethoxyreserpiline, 11-demethoxyreserpiline, reserpiline and &#x3b1;-yohimbine. The present invention also relates to processes for obtaining antipsychotic extracts as well as for the isolation of alkaloids of formula 1 and 2 from the leaves of. The present invention particularly relates to significant antipsychotic activity in the MeOH extract, ethylacetate and chloroform fractions ofand in the isolated compounds &#x3b1;-yohimbine, reserpiline and in a mixture 10-demethoxyreserpiline and 11-demethoxyreserpiline in 1:1.5 ratios for treating psychosis without any extra pyramidal symptoms (EPS). 

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The invention provides a method for screening of plant materials as CNS stimulant/depressant using as a model.

Use of drosophila melanogaster as a model for screening psychostimulant plant materials

The present invention provides a novel synergistic composition comprising extract obtained from the plant together with &dgr;-endotoxin, useful in controlling lepidopteran insects, methods for the preparation of the composition and application of the insecticidal composition to standing crops.

Process of its application against lepidopteran insects using Albizzia lebbeck plant extract and Bacilus thuriengiensis delta-endotoxin

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Lucknow, India

Subhash Chandra Singh