Bristol-myers Squibb Compnay

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Dean A Wacker

Mark D Wittman

Ramesh Kumar Sistla

Susheel Jethanand Nara

Srinivas Cheruku

Kandhasamy Sarkunam

Rishikesh Narayan

Soodamani Thangavel

Kumaravel Selvakumar

Rajesh Onkardas Bora

Srinivas Jogi

Firoz Ali Jaipuri

Chandrasekhar Reddy Rachamreddy

Pavan Kalyan Kathi

Nagalakshmi Pulicharla

Mallikarjuna Rao Mettu

Jalathi Surendran Nair

Sakthi Kumaran Janakiraman

Shilpa Maheshwarappa Holehatti

Arul Mozhi Subbiah Karuppiah

Erika MV Araujo

Disclosed are compounds of Formula (I): or a stereoisomer, a tautomer, or a salt or solvate thereof, wherein Q is Calkenyl or Calkynyl, each substituted with zero to 2 R; and the other variables are as defined herein. These compounds modulate the activity of farnesoid X receptor (FXR), for example, as agonists. Also disclosed are pharmaceutical compositions comprising these compounds and methods of treating a disease, disorder, or condition associated with FXR dysregulation, such as pathological fibrosis, transplant rejection, cancer, osteoporosis, and inflammatory disorders, by using the compounds and pharmaceutical compositions.

Substituted bicyclic compounds as farnesoid X receptor modulators

Disclosed are compounds of Formula (I) or a stereoisomer, a tautomer, or a pharmaceutically acceptable salt or solvate thereof, wherein Q is a 5-membered heterocyclyl or 5-membered heteroaryl having 1 to 4 heteroatoms independently selected from N, O, and S, substituted with zero to 4 R; and A, X, X, X, X, Z, Z, R, R, R, R, a, b, and d are defined herein. Also disclosed are methods of using these compounds to modulate the activity of farnesoid X receptor (FXR); pharmaceutical compositions comprising these compounds; and methods of treating a disease, disorder, or condition associated with FXR dysregulation, such as pathological fibrosis, transplant rejection, cancer, osteoporosis, and inflammatory disorders, by using the compounds and pharmaceutical compositions.

Substituted amide compounds useful as farnesoid X receptor modulators

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Bengaluru, India

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