Pfizer Corporation

Wyeth Holdings Corporation

Subas Man Sakya

Martha L Minich

Bryson Rast

Hengmiao Cheng

Kristin M Lundy

Andrei Shavnya

Jin Li

Mark Edward Ruppen

Phaik-Eng Sum

Philip Albert Carpino

Russell Dushin

Peter Bertinato

Kiyoshi Kawamura

Kazuo Ando

Brian S Bronk

Chikara Uchida

Jason Arnold Lotvin

Haiyin He

Howard Hancock Newman

Tomoki Kato

Michael Greenstein

Ping Cai

Darren Robert Abbanat

Valerie Sue Bernan

Arthur Bailey

Hengmaio Cheng

FangMing Kong

Jason K Dutra

Alan Gordon Sutherland

Kristin Lundy DeMello

Stanley Albert Lang

Ting-Zhong Wang

Compounds of Formula (I) or (II) that act as cannabinoid receptor ligands and their uses in the treatment of diseases linked to the mediation of the cannabinoid receptors in animals are described herein 

Cannabinoid receptor ligands and uses thereof

The present invention relates to heterocyclo alkylsulfonyl pyrazoles of the formula I: wherein the ring of the formula (R)&#x2014;A&#x2014;(SOR), m, X, Rthrough Rare as defined in the specification, to pharmaceutical compositions containing them and to their medicinal use. The compounds of the invention are useful in the treatment or alleviation of inflammation and other inflammation associated disorders, such as arthritis, colon cancer, and Alzheimer's disease in mammals, preferably humans, dogs, cats and livestock animals.

Heterocyclo-alkylsulfonyl pyrazoles

The invention provides compounds of formulaWherein R, R, R, R, R, R, R, R, R, Rand Rare defined in the specification. These compounds are useful as antibiotic agents.

Glycopeptide antibiotics

The present invention relates to compounds of the formulawherein R, R, R, R, and A are defined as in the specification, to pharmaceutical compositions containing them and to their medicinal use. The compounds of the invention are useful in the treatment of inflammation and other inflammation associated disorders, such as osteoarthritis, rheumatoid arthritis, colon cancer and Alzheimer's disease, in mammals (preferably humans, dogs, cats and livestock).

Heterocyclo-alkylsulfonyl pyrazoles as anti-inflammatory/analgesic agents

The present invention relates to 5-heteroatom-substituted pyrazoles of the formula I:

5-heteroatom-substituted pyrazoles

The present invention relates to compounds of the formula:wherein R, R, R, R, R, R, R, R, A, X and Y are defined as in the specification, to pharmaceutical compositions containing them and to their medicinal use. The compounds of the invention are useful in the treatment or alleviation of inflammation and other inflammation associated disorders, such as arthritis, colon cancer, and Alzheimer's disease in mammals, preferably humans, dogs, cats and livestock animals.

Pyrazole ether derivatives as anti-inflammatory/analgesic agents

The present invention relates to compounds of the formulawherein R, R, Rand A are defined as in the specification, to pharmaceutical compositions containing them and to their medicinal use. The compounds of the invention are useful in the treatment of inflammation and other inflammation associated disorders, such as osteoarthritis, rheumatoid arthritis, colon cancer and Alzheimer's disease, in mammals (preferably humans, dogs, cats and livestock).

Sulfonyl heteroaryl triazoles as anti-inflammatory/analgesic agents

The present invention relates to hydrazinyl and nitrogen oxide pyrazoles of the formula I:wherein the ring of the formula (R)-A-(SOR), m, X, Rthrough Rare as defined in the specification, to pharmaceutical compositions containing them and to their medicinal use. The compounds of the invention are useful in the treatment or alleviation of inflammation and other inflammation associated disorders, such as arthritis, colon cancer and Alzheimer's disease in mammals, preferably humans, dogs, cats and livestock animals.

Hydrazinyl and nitrogen oxide pyrazoles

The present invention relates to 5-(alkylidene-cycloalkyl)-pyrazoles and 5-(alkylidene-heterocyclyl)-pyrazoles of the formula I:wherein the ring of the formula (R)-A-(SOR), m, B, ring G, Rthrough Rare as defined in the specification, to pharmaceutical compositions containing them and to their medicinal use. The compounds of the invention are useful in the treatment or alleviation of inflammation and other inflammation associated disorders, such as arthritis, colon cancer, and Alzheimer's disease in mammals, preferably humans, dogs, cats and livestock animals.

5-(alkylidene-cycloalkyl)-and 5-(alkylidene-heterocyclyl)-pyrazoles

Heteroaryl phenyl pyrazole compounds as anti-inflammatory/analgesic agents

5-heterocyclo-pyrazoles

Pyrazole derivatives as anti-inflammatory/analgesic agents

Heterocyclo-alkylsulfonyl pyrazole derivatives as anti-inflammatory/analgesic agents

This invention relates to compounds of formulas 1 and 2 ##STR1## and to pharmaceutically acceptable salts and solvates thereof, wherein X, X.sup.1, R.sup.1, R.sup.2, R.sup.7, R.sup.17 and R.sup.19 are as defined herein. The compounds of formulas 1 and 2 may be useful in the treatment of bacterial, parasitic and protozoal infections, as well as disorders related to bacterial, parasitic and protozoal infections, in mammals, fish and birds. The invention also relates to pharmaceutical compositions containing the compounds of formula 1 and 2 and to methods of treating bacterial, parasitic and protozoal infections by administering the compounds of formula 1 and 2.

3,6-ketal and enol ether macrolide antibiotics

Growing community of inventors

East Lyme, CT, United States of America

Subas Man Sakya