Watson Laboratories Inc.

Subakar Paramanantham

Martyn A Brown

Natalie Lazarowych

Xuejun Liu

Moises Rodriguez

Laura Jong

Azam Mirzahossein

Harpreet Kaur

Ilya Avrutov

Melanie Kelly

Andy Tjeng

Charles Campbell

Randy Ringuette

Prabin Nepal

Monika Garg

Zemin Li

Valeriy Mikaylo

Ofer Yifrach-Stav

Erin Bassett

Disclosed herein are methods, processes and compositions for preparing a compound of formula 8: (8), and formula 18: (18). The methods and processes comprise performing a first allylic oxidation, a protection reaction, a second allylic oxidation, a reduction reaction, performing an acid-catalyzed coupling reaction, a methylation reaction and a deprotection reaction. Disclosed herein are methods, processes and compositions for enantioselectively preparing compounds of formulae 8 and 18. Also disclosed herein are compositions comprising compounds of formulae 8, 18 and/or intermediates and/or starting material thereof.

Methods, processes, and compositions for improved preparation of HU308 and HU433

An improved process is provided for the synthesis of hexahydrodibenzo[b,d]pyran-9-ones, such as nabilone.

Synthesis of hexahydrodibenzopyranones

Growing community of inventors

Scarborough, Canada

Subakar Paramanantham