Viral Technologies, Inc.

Hoffmann-la Roche Inc.

Washington University

Sciclone Pharmaceuticals, Inc.

Alpha 1 Biomedicals

Su-Sun Wang

Allan L Goldstein

John E McClure

Analogs of thymosin &agr;1

Vaccines effective in the inhibition of infection caused by the family of retroviruses, HTLV-III, Human T-Cell Leukemia Virus, LAV, Lymphadenopathy-associated virus, ARV-2, AIDS-Related Virus, (AIDS and AIDS-Related Complex) have been developed from an antisera prepared against thymosin .alpha..sub.1 (T.alpha..sub.1), a thymic hormone, as well as from antisera to synthetic peptide fragments of T.alpha..sub.1 and antisera to synthetic peptide fragments inclusive of amino acid positions 92-109 of the p17 gag core protein of HTLV-III, LAV and ARV-2. In this 18 amino acid primary sequence there is a 44 to 50% homology between the gag protein and T.alpha..sub.1. Immunoglobulin (IgG)-enriched preparations of the T.alpha..sub.1 antisera have enhanced activity in blocking vital replication. A diagnostic test capable of directly detecting the presence of HTLV-III, LAV, ARV-2 and related retroviruses associated with AIDS and ARC is also described.

Diagnastic method and test kit for the serological detection of the AIDS

Thymosin alpha-1 derivatives

Vaccines effective in the inhibition of infection caused by the family of retroviruses, HTLV-III, Human T-Cell Leukemia Virus, LAV, Lymphadenopathy-associated virus, ARV-2, AIDS-Related Virus, (AIDS and AIDS-Related Complex) have been developed from an antisera prepared against thymosin .alpha..sub.1 (T.alpha..sub.1), a thymic hormone, as well as from antisera to synthetic peptide fragments of T.alpha..sub.1 and antisera to synthetic peptide inclusive of amino acid positions 92-109 of the p17 gag core protein of HTLV-III, LAV and ARV-2. In this 18 amino acid primary sequence that is a 44 to 50% homology between the gag protein and T.alpha..sub.1. Immunoglobulin (IgG)- enriched preparations of the T.alpha..sub.1 antisera have enhanced activity in blocking viral replication. A diagnostic test capable of directly detecting the presence of HTLV-III, LAV, ARV-2 and related retroviruses associated with AIDS and ARC is also described.

HIV related peptides, immunogenic antigens, and use therefor as subunit

An improved radioimmunoassay for the polypeptidic thymic hormone thymosin.alpha..sub.1 is described. The assay employs a radiolabelled [Tyr.sup.1 ]-thymosin.alpha..sub.1 or [Tyr.sup.1 ]-desacetylthymosin.alpha..sub.1 as probe and an affinity purified thymosin.alpha..sub.1 antibody of improved selectivity.

Radioimmunoassay of thymosin.alpha.

Growing community of inventors

Belmont, CA, United States of America

Su-Sun Wang