Korea Research Institute of Bioscience and Biotechnology

Su-Kyung Lee

Byoung-Mog Kwon

Kwang-Hee Son

Dong Cho Han

Dong-Cho Han

Dae-Seop Shin

Hye-Nan Kim

Jae-Young Yang

Young-Min Han

Jung-Min Kim

Young-Hee Kho

Hyo-Kon Chun

Disclosed herein is an anticancer composition, comprising obovatol, represented by the following Chemical Formula 1, obovatal, represented by the following Chemical Formula 2, and/or pharmaceutical salts thereof. The composition exhibits the activity of inhibiting the growth of cancer cells and suppressing the expression and activity of matrix metalloproteinases (MMPs), and thus can be useful for the prophylaxis and treatment of cancer as well as for the inhibition of cancer metastasis. 

Anticancer composition comprising obovatol or obovatal

Disclosed herein are novel obovatol derivatives represented by Chemical Formula 1, and pharmaceutically acceptable salts thereof. Having the ability to inhibit the growth of cancer cells and induce apoptosis in cancer cells, the derivatives or pharmaceutically acceptable salts thereof are useful in the prevention and treatment of cancer and in the suppression of cancer metastasis. Also, a method for preparing the derivatives, and pharmaceutical compositions comprising the derivatives as active ingredients are disclosed. 

Obovatol derivatives or pharmaceutically acceptable salts thereof, preparation method thereof and pharmaceutical composition for the prevention and treatment of cancer containing the same as an active ingredient

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Bugi-myeon, South Korea

Su-Kyung Lee