Cj Cheiljedang Corporation

G&p Bioscience Co., Ltd.

Lg Innotek Co., Ltd.

Netmarble Corporation

Reyon Pharmaceutical Co., Ltd.

Viromed Co., Ltd.

Su Jin Park

Young Lyeol Yang

Kyoung Min Lee

Hye Won Um

Hong Xian Li

Hee Kyoung Jung

Hyo Hyoung Lee

Baek Seok Lee

Sun Young Lee

Kwang Ho Lee

Hye Won Kim

Jun Ok Moon

Byeong Cheol Song

Sang Jo Lim

Chang Gyeom Kim

Jae Woo Jang

Seon Hye Kim

Han Hyoung Lee

Sun Young Park

Dong Woo Lee

Sun Young Kim

Jong Hyun Yoon

Sang Hee Park

Min Gyeong Kang

Jihyun Shim

Kyungsu Na

Hyun-jung Bae

Haena Oh

Sang Hoon Yoon

Jeong Won Park

Chang Yub Oh

Kyung Su Na

Il Hwan Seo

Won Sik Gwak

Seong-Hyun Ho

Hyun Ju Won

Hongxian Li

Byung Wook Cho

Sun Keun Shim

Hee Beom An

Soo Man Yun

Yu Jin Han

Hye Jeong Jeong

Seong Hyun Ho

Kyu Dong Kang

Gyu Ho Park

Hyeon Woo Sim

Jin Yong Choi

Hae Kwan Eo

Seon-Hee Kim

The present disclosure relates to a composition for increasing the expression of a growth factor gene, which contains core-shell structured microparticles as an active ingredient. When administered in vivo along with a growth factor gene, the composition for increasing the expression of a growth factor gene of the present disclosure can increase the expression of the co-administered gene by at least 30%. Especially, when administered along with at least one gene selected from a human hepatocyte growth factor (HGF) gene, an isoform gene of the human hepatocyte growth factor and a variant gene thereof, or at least one gene selected from a human insulin-like growth factor 1 (IGF1) gene, an isoform gene of the human insulin-like growth factor 1 and a variant gene thereof, which are appropriate for the present disclosure, the composition can increase the expression of the gene by at least 30%. When administered along with a gene therapeutic agent, the composition can achieve a therapeutic effect even with a very small amount of a gene, and thus is useful.

Composition for increasing the expression of a growth factor gene, comprising coreshell structured microparticles as active ingredient

The present disclosure relates to development of a eukaryotic cell expression vector satisfying optimized conditions for gene therapies and DNA vaccines. As a result of replacing the full HCMV regulatory and transcribed region including the immediate early (IE) gene intron A of the HCMV Towne strain and the same region of various HCMV strains at the pVAX1 promoter region and comparing the difference in gene expression efficiency for the different HCMV strains, the eukaryotic cell expression vector of the present disclosure could increase the expression of various genes by about 50-150% as compared to the HCMV Towne strain. Through this, pHP3 was developed as a vector exhibiting high expression in eukaryotic cells, and it can be usefully used for gene therapies or DNA vaccines.

Development of optimized recombinant expression construct

The present disclosure relates to a novel polypeptide having an ability to export an ornithine-based product, and a method for producing an ornithine-based product using the same.

Modified polypeptide having an activity of ornithine-based product exporter and method for producing ornithine-based product using cells expressing the polypeptide

Disclosed is a game test automation device capable of automating a game test. The game test automation device can comprise: a database for storing test procedure information, which is a combination of game scripts to be tested in a game service; and a testing unit for testing game build of the game service on the basis of the test procedure information, and creating game state information derived in the testing process and a test report on the test.

Game test automation device and method

Disclosed is a modified microorganism producing putrescine or ornithine, and a method for producing putrescine or ornithine using the same.

Microorganism for producing ornithine and process for producing ornithine using them

Microorganisms for producing putrescine or ornithine and process for producing putrescine or ornithine using them

The present invention relates to a recombinant microorganism for producing putrescine or ornithine, and a method for producing putrescine or ornithine using the same. Specifically, the present invention relates to a microorganism of the genuscapable of producing putrescine or ornithine, in which an activity of the transcriptional regulator of sugar metabolism (SugR) is weakened, an activity of the citrate synthase (GltA) is enhanced, or both are applied; and a method for producing putrescine or ornithine using the same.

The present invention relates to a recombinant microorganism capable of producing putrescine, in which the microorganism is modified to have enhanced NCgl2522 activity, thereby producing putrescine in a high yield, and a method for producing putrescine using the microorganism.

Microorganisms having putrescine productivity and process for producing putrescine using the same

Polypeptide and method for producing ornithine-based product using the same

Microorganisms for producing putrescine and process for producing putrescine using them

The present invention relates to a microorganism for producing diamine, in which activity of a protein having an amino acid sequence of SEQ ID NO: 6 or an amine acid sequence having 42% or higher sequence homology with SEQ ID NO: 6 is introduced or enhanced, and a method of producing diamine using the same.

Microorganisms for producing diamine and process for producing diamine using them

The present invention relates to a microorganism for producing diamine, in which activity of a protein having an amino acid sequence of SEQ ID NO: 6 or an amino acid sequence having 42% or higher sequence homology with SEQ ID NO: 6 is introduced or enhanced, and a method of producing diamine using the same.

The present invention relates to a microorganism for producing diamine, in which activity of a protein having an amino acid sequence of SEQ ID NO: 6 or an amino acid sequence having 55% or higher sequence homology with SEQ ID NO: 6 is introduced or enhanced, and a method of producing diamine using the same.

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Seoul, South Korea

Su Jin Park