Aventis Pharma S.a.

Sanofi-Aventis

Sanofi

Stéphanie Deprets

Frank Halley

Laurent Schio

Olivier Duclos

Jidong Zhang

Fabienne Thompson

Sergio Mallart

Maria Mendez-Perez

Vincent Leroy

Yannick Benedetti

Francois Clerc

Anke Steinmetz

Chantal Carrez

Fabrice Vergne

Fabienne Chatreaux

Odile Angouillant-Boniface

Dominique Melon-Manguer

François Clerc

Daniel Bezard

Francois Hamy

Georges Delettre

Isabelle Depaty

Manfred Roesner

The invention relates to a compound of formula (I), where: Ris a phenyl group optionally substituted by one or more halogen atoms; Ris: a hydrogen atom or a halogen atom or a cyano group; a &#x2014;C(&#x2550;O)Y group where Y is a hydrogen atom, or a &#x2014;NHor &#x2014;ORgroup; a &#x2014;C(&#x2550;S)NHgroup; a &#x2014;C(&#x2550;NH)NH&#x2014;OH group; a &#x2014;CHOH or &#x2014;CHF group; a &#x2014;CH&#x2550;N&#x2014;OH group; a &#x2014;CH&#x2550;CHor &#x2014;C&#x2550;C&#x2014;Rgroup; a H or H Rgroup being a hydrogen or (C-C)alkyl group; Ris a hydrogen atom or (C-C)alkyl group; and Ris a &#x2014;NH, (C-C)alkyl, (C-C)fluoroalkyl or (C-C)cycloalkyl group. 

1-pyrazolo[4,3-c]isoquinoline derivatives, preparation thereof and therapeutic use thereof

The invention especially relates to novel chemical compounds, especially novel benzothiazole derivatives, to compositions containing said compounds, and to the use thereof as medicaments.

Benzothiazoles and the use thereof as medicaments

The present invention discloses and claims benzimidazole compounds of formula (I):in which A is aryl or heteroaryl; Ris selected from optionally substituted alkyl, alkoxy, aryl or heteroaryl, NH-lower alkyl or NH-cycloalkyl, or halogen, NH; 1-imidazolyl or SOMe; Ris selected from optionally substituted &#x2014;CO-alkyl, &#x2014;CO-cycloalkyl, &#x2014;CO-aralkyl, &#x2014;CO-aryl, &#x2014;CO-alkoxy, aryl or aralkyl, or &#x2014;CO-amino, CO&#x2014;NHRor CO&#x2014;RRwherein Rand Rare selecteded independently from hydrogen, alkyl, hydroxyalkyl, alkoxyalkyl, fluoroalkyl, alkynyl, heteroalkyl, alkylheteroalkyl, aryl, aralkyl or together form an alkylene chain optionally containing one to 4 heteroatoms; a pharmaceutically acceptable salt or a prodrug thereof; the use of compounds of formula (I) for the treatment of cancer, and pharmaceutical compositions comprising a compound of formula (I) and one or more pharmaceutically acceptable adjuvants or diluents.

Substituted benzimidazole compounds and their use for the treatment of cancer

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Paris, France

Stéphanie Deprets