Nitto-denko Corporation

Altea Therapeutics Corporation

Other

Spectrx, Inc.

Altea Technologies, Inc.

Stuart McRae

Jonathan Eppstein

Zoran Novakovic

Bernadette Messier

Jeremiah P O'Leary

Mark James Fisher

Alan Smith

David Farquhar

Stephen Wilson Braun

Uros Kascak

Loren J Lantz

Erin Koch Henkel

Regina Spiehl

Wendy E Bowerman

Michael R Hatch

Joseph Papp

A transdermal permeant delivery of at least one permeant composition into a tissue membrane of a subject including a disposable substrate having at least a portion of a bottom surface of a first release liner connected to an upper surface of the substrate and a patch having a backing layer and a reservoir that is selectively removable from the top surface of the first release liner. In a connected position, a first portion of the backing layer of the patch is releaseably mounted to a top surface of the first release liner in spaced registration with a poration area of the substrate.

Transdermal porator and patch system and method for using same

Providing a method for monitoring an analyte extracted from a patient and delivering a permeant composition to the patient. The method includes the steps of a) contacting a poration device to a tissue membrane of the patient, the poration device including at least one porator array; b) actuating poration of the tissue membrane using the at least one porator array in the poration device; c) extracting the analyte from the porated tissue membrane by way of the at least one porator array; d) analyzing the analyte to determine a concentration of the analyte within the tissue membrane; and e) delivering a permeant composition to the tissue membrane by way of the at least one porator array.

Transdermal integrated actuator device, methods of making and using same

A method for delivering permeant substances transdermally into a membrane of an animal includes forming at least one delivery opening in the skin tissue, with the at least one delivery opening having a mean opening depth of between about 40 and about 90 microns.

Method for transdermal delivery of permeant substances

The invention provides for a device for delivering a drug comprising: The invention also provides for methods of making and methods of using the same.

A transdermal permeant delivery system for delivery of at least one permeant composition into a tissue membrane of a subject including a disposable substrate having at least a portion of a bottom surface of a first release liner connected to an upper surface of the substrate and a patch having a backing layer and a reservoir that is selectively removable from the top surface of the first release liner. In a connected position, a first portion of the backing layer of the patch is releaseably mounted to a top surface of the first release liner in spaced registration with a poration area of the substrate.

The invention provides for an integrated device for forming a cavity in a surface of a tissue of an animal comprising: The invention also provides for methods of making and methods of using the same.

The invention provides for a transdermal drug delivery device for forming a drug delivery patch system comprising: The invention also provides for methods of making and methods of using the same.

Transdermal drug delivery patch system, method of making same and method of using same

A transdermal drug delivery device for forming a micropore in a tissue membrane of an animal comprising a substrate and a porator that is located on or within the substrate. The porator is constructed of a material that is destroyed upon forming the micropore. The transdermal drug delivery device also comprises at least one reservoir and a controller for controlling the formation of said micropore by the porator and destroying the porator after the formation of the micropore.

Transdermal drug delivery device, method of making same and method of using same

A system and method for detecting a measuring an analyte in a biological fluid of an animal. A harvesting device () is provided suitable for positioning on the surface of tissue of an animal to harvest biological fluid therefrom. The harvesting device () comprises an analyte sensor () positioned to be contacted by the harvested biological fluid and which generates a measurement signal representative of the analyte. At least one attribute sensor () is provided to measure an attribute associated with the biological fluid harvesting operation of the harvesting device () or the assay of the biological fluid, and which generates an attribute signal representative of the attribute. Adjustments are made to operational parameters of the harvesting device () based on the one or more attributes.

Attribute compensation for analyte detection and/or continuous monitoring

A device to facilitate ablation of tissue, such as for forming one or more openings in the tissue for transdermal monitoring and/or delivery applications. The device comprises: (a) a support layer having at least one aperture therein, and (b) at least one energy absorbent film layer disposed over the at least one aperture in the support layer for making substantial contact with tissue through the aperture. The at least one energy absorbent film layer is under a tension force and absorbs energy focused thereon to thermally ablate the tissue. After ablation, the layer breaks apart allowing access to the ablated tissue beneath it.

Growing community of inventors

Atlanta, GA, United States of America

Stuart McRae