The University of Manchester

Mayo Foundation for Medical Education and Research

The University of British Columbia

Vib Vzw

Universiteit Antwerpen

Ucl Business Plc

University College Cardiff Consultants Limited

National Institute of Aging

Hospital District of Helsinki and Uusimaa

Vu University Medical Centre Armsterdam

Stuart M Pickering-Brown

Jason Eriksen

Michael L Hutton

Christine Van Broeckhoven

Jennifer Mae Gass

Ashley Diane Cannon

Ian Reid Alexander Mackenzie

Rosa Rademakers

Howard Feldman

Samir Kumar-Singh

Matthew Charles Baker

Marc Cruts

Andrew Barry Singleton

Peter Heutink

Bryan Traynor

John Hardy

Huw Morris

Pentti Tienari

The present invention relates to methods of assessing whether a subject has or is likely to develop a neurodegenerative disease comprising determining whether the subject has a mutation in the C9orf72 gene wherein said mutation prevents or disrupts C9orf72 expression relative to expression in a reference from subjects without the mutation.

Method for diagnosing a neurodegenerative disease

This document relates to methods and materials for detecting mutations that can be linked to dementia. For example, methods and materials for detecting one or more mutations within PGRN nucleic acid are provided. This document also provides methods and materials for detecting the level of progranulin expression. In addition, this document relates to methods and materials for treating mammals having a neurodegenerative disorder (e.g., dementia). For example, methods and materials for increasing PGRN polypeptide levels in mammals are provided, as are methods and materials for identifying agents that can be used to increase PGRN polypeptide levels in mammals.

Detecting and treating dementia

Growing community of inventors

Derbyshire, United Kingdom

Stuart M Pickering-Brown