Pharmacia & Upjohn Company

Stuart Lam

Dinesh Vinoobhai Patel

Adam Renslo

Mikhail Fedorovich Gordeev

Gary W Luehr

Neil E Westlund

The present invention provides a compound of formula I or a pharmaceutically acceptable salt thereof wherein Y is &#x2014;S(&#x2550;O)&#x2014;, &#x2014;S(&#x2550;NR)&#x2014;, or &#x2014;S(&#x2550;NR)(&#x2550;O)&#x2014;; Z is &#x2014;NHC(&#x2550;O)R, &#x2014;NHC(&#x2550;S)R, &#x2014;NH-het, &#x2014;O-het, &#x2014;S-het, or -het. The compounds of formula I are useful as antibacterial agents.

Antimicrobial dihydrothiazine and dihydrothiopyran oxazolidinones

The present invention provides a compound of formula Ior a pharmaceutically acceptable salt thereof wherein A is a structure i, ii, iii, or ivX is CR; Y is &#x2014;S(&#x2550;O)&#x2014;, &#x2014;S(&#x2550;NR)&#x2014;, or &#x2014;S(&#x2550;NR)(&#x2550;O)&#x2014;; Z is &#x2014;NHC(&#x2550;O)R, &#x2014;NHC(&#x2550;S)R, &#x2014;NR-het, &#x2014;O-het, &#x2014;S-het, or -het; and n is independently 0, 1, or 2. The compounds of formula I are useful as antimicrobials against a number of human and veterinary pathogens.

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San Francisco, CA, United States of America

Stuart Lam