Wisconsin Alumni Research Foundation

University of Delaware

The Ohio State University

North Carolina State University

The University of North Carolina at Chapel Hill

Stuart L Cooper

Timothy G Grasel

Chris Zhisheng Chen

Cam Patterson

Anka N Veleva

Chi Li

Provided herein are compositions and methods for binding outgrowth endothelial cells (OEC). The compositions consist of peptide ligands capable of binding OEC with high affinity and specificity. The compositions of the invention include peptides set forth in SEQ ID NO: 1-38 and variants and derivatives thereof. Compositions also include the nucleotide sequences encoding the peptides of the invention. The compositions find use in methods for the isolation of OEC and for the recruitment and retention of OEC to sites of therapeutic interest. Methods for the identification and isolation of other peptides capable of binding OEC are also provided.

Peptides specific for human blood outgrowth endothelial cells

A novel cationic dendrimer biocide-silver nanocomposite and methods for its use as a biocide. The biocidal nanocomposites of the present invention are effective against a variety of microbial species, including anthrax. The invention is also highly stable and safe for exposure to human skin. The invention has applications as an antibiological warfare agents, antimicrobial agent for surface coatings and as a general biocide that is safe for human exposure.

Dendrimer biocide-silver nanocomposites: their preparation and applications as potent antimicrobials

Quaternary ammonium functionalized dendrimers are described which are suitable for controlling the growth of microorganisms. The quaternary ammonium functionalized dendrimer biocides of the present invention are effective against a wide variety of microbial species including bacteria, spores, yeast, fungi, mold and multicellular microorganisms.

Quaternary ammonium functionalized dendrimers and methods of use therefor

Polysiloxane-containing polyurea and polyurea urethane block copolymers and devices formed therefrom are biocompatible and demonstrate improved physical and mechanical properties. The pre-reaction of an amine-terminated polysiloxane soft segment with an organic diisocyanate provides an oligomer that enhances the hydrophilic properties of the copolymer.

Polysiloxane polyurea urethanes

Modified-polyurethane block copolymers and devices formed therefrom demonstrate excellent biocompatibilty and improved physical and mechanical properties. In a preferred embodiment, from about 5 to about 25 percent of urethane hydrogen atoms are replaced with propyl sulfonate and propyl carboxylate groups to provide the modified copolymer.

Biocompatible polyurethane devices wherein polyurethane is modified with

Modified-polyurethane block copolymers and devices formed therefrom demonstrate excellent biocompatibility and improved physical and mechanical properties. In a preferred embodiment, from about 5 to about 25 percent of urethane hydrogen atoms are replaced with propyl sulfonate and propyl carboxylate groups to provide the modified copolymer.

Growing community of inventors

Madison, WI, United States of America

Stuart L Cooper