Reviral Limited

Glaxo Group Limited

Stuart George Cockerill

Neil Mathews

David Kendall Jung

Richard Angell

Ian Robert Baldwin

Michael Robert Peel

James Good

Stephen Sean Flack

Jennifer Gabriel Badiang

Simon Ward

James Lumley

Christopher Pilkington

Matthew Barrett

Jose Miguel Gascon Simorte

Michael Paradowski

Graham Lunn

Michael John Alberti

Mui Cheung

Philip Anthony Harris

Kirk Stevens

James Marvin Veal

Benzimidazole derivatives of formula (I): wherein: Ris &#x2014;(CH)m-Ror Ris halo, &#x2014;(CH)&#x2014;NHor &#x2014;(CH)&#x2014;C(&#x2550;NH)&#x2014;NH; Ris H or F; Ris &#x2014;NH&#x2014;(CH)&#x2014;(NH)&#x2014;R, &#x2014;NH&#x2014;(CHRR) or a group of the following formula (A): (A) W is &#x2014;(CH)&#x2014;, &#x2014;CH&#x2014;O&#x2014;CH&#x2014;, &#x2014;CH&#x2014;S&#x2014;CH&#x2014;, &#x2014;(CH)&#x2014;S(O)&#x2014;CH&#x2014; or &#x2014;(CH)&#x2014;NR&#x2014;CH&#x2014;; m is an integer of 1 to 3; n is 1 or 2; p is 1 and V is CH; or p is O and V is N; q is 0 or 1; r is 0 or 1; Ris H, &#x2014;SOMe, &#x2014;SOEt, &#x2014;SOCF, &#x2014;COMe, &#x2014;CONMe, &#x2014;CONHor &#x2014;CHCHSOMe; Ris H or C-Calkyl; and Ris &#x2014;SOMe, &#x2014;SOEt, &#x2014;SOCF, &#x2014;COMe, &#x2014;CONMe, &#x2014;CONHor &#x2014;CHCHSOMe; and the pharmaceutically acceptable salts thereof are inhibitors of RSV and can therefore be used to treat or prevent an RSV infection. 

Pharmaceutical compounds

Pyrimidine derivatives of formula (I) wherein: Z is a direct bond or &#x2014;(CH)&#x2014; wherein n is 1 or 2; one of X and Y is N, CH or CF, and the other of X and Y is CH; one of Rand Ris selected from &#x2014;NHR, &#x2014;NR, &#x2014;OR, &#x2014;SR, &#x2014;S(O)R, &#x2014;S(O)R and a group of the following formula (A) and the other of Rand Ris selected from &#x2014;NHR', &#x2014;OH, &#x2014;OR&#x2032; and a group of the above formula (A); R is unsubstituted C-Calkyl; R&#x2032; is a group selected from C-Calkyl, 5- to 12-membered aryl and C-Ccycloalkyl, which group is unsubstituted or substituted; W is &#x2014;(CH)&#x2014;, &#x2014;CH&#x2014;O&#x2014;CH&#x2014;, &#x2014;CH&#x2014;S&#x2014;CH&#x2014; or &#x2014;CH&#x2014;S(O)&#x2014;CH&#x2014;; p is 1, q is an integer of 1-6 and V is N; or p is 1, q is 0 and V is CH; or p is 0, q is 0 and V is N; r is 0 or 1; and Ris &#x2014;(CH)&#x2014;NHor &#x2014;(CH)&#x2014;OH wherein s is 0 or an integer of 1 to 4; and the pharmaceutically acceptable salts thereof are inhibitors of RSV and can therefore be used to treat or prevent an RSV infection. 

Pyrimidine derivatives and their use in treating or preventing a respiratory syncytial virus infection

Benzimidazoles of formula (I): wherein: one of X and Y is an N atom or a substituted C atom, and the other is CH; L is a single bond, Calkylene, Calkenylene or Calkynylene; Ris Calkyl, Calkenyl, Calkynyl, 3- to 10-membered cycloalkyl, 5- to 10-membered heterocyclyl or 5- to 12-membered heteroaryl, each of which is unsubstituted or substituted; Z is halo, Chaloalkyl, nitro, &#x2014;CN, &#x2014;N(R)2, &#x2014;OR, &#x2014;SR, &#x2014;S(=0)R, or &#x2014;S(=0)R; each Ris independently hydrogen, Calkyl, Calkenyl or C2-6 alkynyl, wherein said alkyl, alkenyl and alkynyl groups are unsubstituted or substituted; and m is 0 or 1; and the pharmaceutically acceptable salt thereof are inhibitors of RSV and can therefore be used to treat or prevent an RSV infection. 

Spiro-indolines for the treatment and prophylaxis of respiratory syncytial virus infection (RSV)

Benzimidazoles of formula (I): wherein: A is 5- to 12-membered aryl or 5- to 12-membered heteroaryl, each of which is unsubstituted or substituted; Y is a single bond, &#x2014;(CH)&#x2014;, &#x2014;X&#x2014;, &#x2014;CH&#x2014;X&#x2014;, or &#x2014;X&#x2014;CH&#x2014;; X is &#x2014;O&#x2014;, &#x2014;S&#x2014;, &#x2014;N(R)&#x2014;, &#x3e;C&#x2550;O, &#x3e;S(&#x2550;O), &#x3e;S(&#x2550;O), &#x2014;O&#x2014;C(&#x2550;O)&#x2014;, &#x2014;C(&#x2550;O)&#x2014;O&#x2014;, N(R)&#x2014;C(&#x2550;O)&#x2014;, or &#x2014;C(&#x2550;O)&#x2014;N(R)&#x2014;; each L is independently a single bond, Calkylene, Calkenylene or Calkynylene; Ris Calkyl, Calkenyl or Calkynyl, each of which is unsubstituted or substituted; each Z is independently &#x2014;N(R), &#x2014;OR, &#x2014;SR, &#x2014;S(&#x2550;O)R, &#x2014;S(&#x2550;O)R; each Ris independently hydrogen, Calkyl, Calkenyl or Calkynyl, wherein said alkyl, alkenyl and alkynyl groups are unsubstituted or substituted; m is 0, 1, 2, or 3; n is 1, 2, or 3; and p is 1, 2, or 3; and the pharmaceutically acceptable salt thereof are inhibitors of RSV and can therefore be used to treat or prevent an RSV infection. 

Compounds of Formula (I): salts or solvates or physiologically functional derivatives thereof, wherein Z is CH or N, and R, R, and Rare various substituent groups, are protein kinase inhibitors 

Fused pyrazole derivatives being protein kinase inhibitors

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Stevenage, United Kingdom

Stuart George Cockerill