Astrazeneca Ab

Stuart Eric Pearson

Jason Grant Kettle

Martin John Packer

James Michael Smith

Robert Hugh Bradbury

Elizabeth Janet Pease

Emma Jane Williams

Tudor Grecu

Roger James

Anthony Michael Slater

Rolf Peter Walker

Peter Wr Caulkett

The invention concerns compounds of Formula (I): or pharmaceutically acceptable salts thereof, wherein R, R, Rand Rhave any of the meanings hereinbefore defined in the description; process for their preparation, pharmaceutical compositions containing them and their use in treating KIT mediated diseases. 

Phenoxyquinazoline compounds and their use in treating cancer

The invention concerns compounds of Formula (I): or pharmaceutically acceptable salts thereof, wherein R, R, Rand Rhave any of the meanings hereinbefore defined in the description; process for their preparation; pharmaceutical compositions containing them and their use in treating KIT mediated diseases.

C-anilinoquinazoline compounds and their use in treating cancer

C5-anilinoquinazoline compounds and their use in treating cancer

Pyrimidine derivatives of formula (I) wherein Q, Q, G and Rare as defined within; and pharmaceutically acceptable salts and in vivo hydrolysable esters thereof are described. Processes for their manufacture, pharmaceutical compositions and their use as cyclin-dependent serine/threonine kinase (CDK) and focal adhesion kinase (FAK) inhibitors are also described.

2,4,DI (hetero-) arylamino (-oxy)-5-substituted pyrimidines as antineoplastic agents

2,4-Di(hetero-)arylamino(-oxy)-5-substituted pyrimidines as antineaoplastic agents

The invention relates to heterocyclic derivatives of formula (I), or pharmaceutically-acceptable salts thereof, which possess antithrombotic and anticoagulant properties and are accordingly useful in methods of treatment of humans or animals. The invention also relates to processes for the preparation of the heterocyclic derivatives, to pharmaceutical compositions containing them and to their use in the manufacture of medicaments for use in the production of an antithrombotic or anticoagulant effect.

Heterocyclic derivatives which inhibit factor Xa

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Cambridge, United Kingdom

Stuart Eric Pearson