Quadrant Technologies Limited

Valois Sas

Btg International Limited

Organo Corporation

Optinose As

Aptar France Sas

Stuart Brian William Kay

Andrew Gordon Pocock

Paul Greenhalgh

Wayne O'Hara

Matthew Egerton Young

Neil Richard Harrison

Constantin Coussios

Michael W Ligotke

Peter John Friend

Christopher John Hurlstone

Martin Joseph Murphy

Leslie James Russell

Per Gisle Djupesland

Anthony David Harman

Xavier Donnette

Philip David Canner

David George Robinson

Brendan Hogan

David Dakin Iowerth Wright

Peter Alan Salkus

Sebastien Antoine Yves Cuvelier

Jonathan Richard Oakley

Julian Richard Dixon

Julina Richard Dixon

Jam Willem Marinus Mijers

Jam Wilem Marinus Mijers

Constantin-C Coussios

A disposable set of components for an organ perfusion system comprising a fluid supply duct for supplying fluid to the organ, a fluid removal duct for removing fluid from the organ, and a surrogate organ removably connected between the fluid supply duct and the fluid removal duct so as to form a fluid circuit, so that fluid can be circulated in the circuit in preparation for connection of the organ.

Organ perfusion systems

An organ perfusion system comprises: a perfusion fluid circuit () arranged to circulate perfusion fluid through the organ; a surrogate organ () arranged to be connected into the circuit in place of the organ so that the circuit can circulate fluid through the surrogate organ; and organ sensing means arranged to distinguish between the presence of the organ in the circuit and the presence of the surrogate organ in the circuit. The sensing means may comprise one or more pressure sensors (), or a flow meter (). Further aspects relate to adjusting the content of at least one component, such as oxygen or a nutrient, in the perfusion fluid. Bubble detection means (), and means () to measure the amount of fluid secreted by or leaked from the organ, may also be provided.

A perfusion system for the perfusion of an organ comprises a perfusion fluid circuit () for circulating perfusion fluid through the organ, oxygenation means () for adding oxygen into the perfusion fluid, and an oxygen supply arranged to supply oxygen to the oxygenation means. The oxygen supply comprises an oxygen concentrator.

Oxygen supply for organ perfusion systems

Syringe for dispensing foam having a syringe barrel, a nozzle and a bore to receive a syringe plunger having a front end and a back end. The syringe plunger includes at the front end thereof a waste container defined by a cylindrical side wall, a front end wall and a rear end wall, the walls being arranged such that an external cylindrical surface of the walls forms a seal with an internal surface of the syringe barrel. The waste container has an inlet aperture in the front end wall which is in communication with the syringe nozzle when the plunger is fully depressed into the syringe barrel. The waste container further has a hydrophobic vent in the rear end wall thereof which allows air to escape from the waste container while substantially preventing foam from escaping the waste container when the syringe is in use.

Apparatus for delivering foam

A breath-actuated delivery device includes a mouthpiece through which a subject in use exhales, an air channel which is in fluid communication with the mouthpiece, and a flexible diaphragm which is disposed in the air channel. The diaphragm provides for at least a restricted air flow through the air channel until a predeterminable actuation pressure is developed in the mouthpiece, and, on generation of the predeterminable actuation pressure in the mouthpiece, provides for an air flow through the air channel.

Delivery devices

An inhaler comprising: at least one cover element () that is movable between a closed position and an open position; individual reservoirs formed on a reservoir substrate; movable support means () that are displaceable between a non-dispensing position and a dispensing position; reservoir opening means () for opening a respective reservoir in the dispensing position; loading means () for urging said movable support means towards said dispensing position; blocking means () for retaining said movable support means in the non-dispensing position; and trigger means () for releasing said blocking means; said loading means including an elastically-deformable loading element () that co-operates with a cam surface () that is connected to said at least one movable cover element; and said cam surface comprising a first portion that is adapted to load said loading means, and a second portion that co-operates with said loaded loading means.

Fluid-product dispensing device

An inhaler comprising: at least one cover element (); individual reservoirs formed on a substrate; support means () that are movable between a non-dispensing position and a dispensing position; reservoir-opening means (); displacement means () for displacing said reservoir substrate in a first direction, said reservoir substrate also being displaceable between said non-dispensing position and said dispensing position in which said opening means open a respective reservoir; loading means () for urging said movable support means towards said dispensing position; blocking means () for retaining said movable support means in the non-dispensing position; trigger means () that are actuated by inhalation; and connection means () for displacing said reservoir substrate in said first direction when said at least one cover element is displaced, said connection means being activated while said movable support means are being displaced towards said dispensing position while the user is inhaling, and being deactivated in the absence of any inhalation.

An inhaler comprising: a body; at least one cover element that is movable between a closed position and an open position; individual reservoirs formed on a reservoir substrate; movable support means that receive said reservoir substrate and that are displaceable between a non-dispensing position and a dispensing position; and an indicator device for indicating doses that have been dispensed or that remain to be dispensed, said indicator device comprising: a rotary indicator element that supports indicator means, such as numbers, colors, and/or symbols; and an actuator that co-operates with said movable support means so as to cause said rotary indicator element to turn when said movable support means return from the dispensing position to the non-dispensing position.

A foam transfer device is described, for use with aerosol canister apparatus for producing a sclerosant foam for the treatment of, inter alia, varicose veins. The device enables diversion of an initial quantity of below-specification foam from the canister to waste, e.g. to an integral waste chamber, before dispensing a further quantity of foam for use in treatment. The switching of the flow from the waste chamber to a different outlet for use is accomplished without interrupting the flow from the aerosol canister since this would cause the foam to drop below specification again. The waste chamber may be transparent so that the foam entering it can be observed and a decision made by a user when to stop diverting foam to waste. Alternatively, the foam may be diverted automatically e.g. when a set time has elapsed or a set volume of foam dispensed. The foam for use is normally dispensed into a syringe for subsequent injection into a varicose vein of a patient.

Apparatus and method for dispensing foam

A unit dose dry powder inhaler has a dispersion chamber, optionally including one or more beads. A blister is supported adjacent to the dispersion chamber. A mouthpiece cover is removable from a mouthpiece, with movement of the mouthpiece cover causing the blister to open. An air flow path extends past or under the blister and into the dispersion chamber. As a result, the blister remains sealed until the inhaler is ready for use. The blister is then automatically opened when the mouthpiece cover is removed from the mouthpiece. Pharmaceutical dry powder is released from the blister and entrained in air flow through the inhaler, when the user inhales on the mouthpiece. The powder is dispersed in air within the dispersion chamber.

Unit dose dry powder inhaler

Apparatus for dispensing foam for the treatment of, inter alia, varicose veins. The apparatus includes a source of foam and a dispensing device which has an inlet in communication with the source of foam, a usable foam outlet, and a waste bleed outlet. The waste bleed outlet communicates with the inlet and with the useable foam outlet, and has a higher resistance to flow of foam than that of the usable foam outlet. The useable foam outlet may be blocked off such that foam may flow through the high resistance waste bleed outlet, and the usable foam outlet may be opened such that foam may flow through the usable foam outlet.

A delivery device, in particular a breath-actuated nasal delivery device, for delivering substance, in particular one of a liquid, as a suspension or solution, or a powder containing a medicament, especially systemic or topical pharmaceuticals, or a vaccine to the nasal airway of a subject.

A dose-indicator device for using with a dispenser device for dispensing fluid or powder, in particular a pharmaceutical, so as to indicate the number of doses that have been emitted or that remain to be emitted from the dispenser device, the indicator device comprising a first rotary disk () and a second rotary disk () that is preferably opaque, said first disk () including indicator numbers and/or symbols () that are disposed in peripheral manner about the axis of rotation (X) of said first rotary disk () around at least two concentric circles, and said second disk () including at least one viewing window ().

Dose indicator device for a fluid or powdery product dispenser

A unit dose dry powder inhaler includes a chamber housing containing a powder dispersion chamber. A chamber tube extends from the dispersion chamber into the mouthpiece. A cover or cup is rotatably attached to the chamber housing. A dose of a dry powder is contained at a powder location in the chamber housing. An air passageway leading from the powder location to the dispersion chamber is closed off by the cover. When the cover is rotated to an open position, the air passageway is opened. The user inhales on the mouthpiece drawing air through the powder location, the air passageway, the dispersion chamber and the chamber tube, through the mouthpiece and into the users lungs. The unit dose of dry powder is stored directly in, or is part of, the inhaler.

Growing community of inventors

Cambridge, United Kingdom

Stuart Brian William Kay