Novartis Ag

Irm LLC

The Scripps Research Institute

Irm Llc, a Delaware Corp.

Stuart Bevan

Ardem Patapoutian

Chuanzheng Song

Pamposh Ganju

Peter McIntyre

Andrea Peier

Gina M Story

This invention provides novel genes and polypeptides of the transient receptor potential channel family, and use of these genes and polypeptides for the treatment of pain and identification of agents useful in the treatment of pain.

Transient receptor potential channel TRPM8 and its use

The methods and compositions of the invention are based on a method for measuring nociceptive responses in vertebrates, including humans and other mammals utilizing a newly discovered thermoreceptor belonging to the Transient Receptor Potential (TRP) family of non-selective cation channels that participates in thermosensation and pain. This receptor, designated ANKTMI, is associated with nociceptive pain, such as hyperalgesia. Accordingly, the invention provides isolated polypeptides and polynucleotides associated with nociception as well as methods for identifying or screening agents that modulate nociception.

ANKTM1, a cold-activated TRP-like channel expressed in nociceptive neurons

Transient receptor potential channel TRPV3 and its use

This invention provides novel genes and polypeptides of the VR family, identification of trkApain specific genes expressed in the DRG, and use of these genes and polypeptides for the treatment of pain and identification of agents useful in the treatment of pain.

Vanilloid receptor-related nucleic acids and polypeptides

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London, United Kingdom

Stuart Bevan