Other

Csl Limited

The University of Queensland

The University of Melbourne

Stirling John Edwards

Elizabeth Ann Webb

Ian Hector Frazer

John Cooper Cox

Margaret Bridget Holland Moloney

Nigel Alan John McMillan

Mark Philip Williams

Mary Brigid Margetts

Martin John Pearse

Jean-Pierre Yves Scheerlinck

Philip Sutton

Phil Sutton

A method for eliciting or inducing an immune response in a human or animal subject, comprises administering to said subject a composition comprising an antigen and an adjuvant, wherein the composition is administered to the subject by the intra-lung route.

Method of elicting or inducing an immune response

A papillomavirus polyprotein construct comprises at least two amino acid sequences fused directly or indirectly together, each of the sequences being the sequence of an early ORF protein of papillomavirus or an immunogenic variant or fragment thereof, and at least one of said sequences being other than the E6 or E7 protein sequence or an immunogenic variant or fragment thereof. Nucleic acid molecules encoding the polyprotein construct, prophylactic or therapeutic compositions comprising the polyprotein construct or the nucleic acid molecule, and methods for eliciting an immune response against papillomavirus in a host animal are also provided.

Papillomavirus polyprotein constructs

Peptides, antibodies and recombinant expression systems or cells that contain and express a DNA insert of HPV encoding a region of a papilloma induced or a papilloma protein, such as E6 or E7, are produced. Compositions containing these peptides, antibodies and/or recombinant cells are utilized as immunogenic compositions and in methods for inhibiting and treating HPV infection and tumor initiation and progression. Specific peptides and recombinant cells, such as vaccinia virus and tumor cells, that express epitopic regions of the HPV16 E6 or E7 nucleoprotein are particularly described.

Variants of human papilloma virus (HPV) E6 and E7 proteins able to elicit a humoral and/or cellular immune response against HPV in a host animal but not being cell-transforming in the host animal are disclosed, and are useful in treatment or prevention of diseases or conditions involving HPV.

Variants of human papilloma virus antigens

A vector system for expressing foreign proteins or polypeptides in bacteria such as,is disclosed. The vector system is especially useful in obtaining expression of non-transforming variants of human papilloma virus antigens.

Method for protein expression

Variants of human papillomavirus antigens

Growing community of inventors

Coburg, Australia

Stirling John Edwards