Centre National De La Recherche Scientifique

Université´de Rouen

Medicago Inc.

Stéphanie Aquin

Louis-Philippe Vezina

Patrice Lerouge

Muriel Bardor

Véronique Gomord

Marc-André D'Aoust

Thomas Paccalet

Christophe Rihouey

Loïc Faye

Carole Burel

Christophe Sourrouille

Estelle Marquet-Blouin

Marc-André D'AOUST

A method of synthesizing sialic acid in plants, and plants capable of synthesizing sialic acid is provided. Furthermore, a method of producing sialylated protein in a plant is also provided. The method to synthesize sialic acid comprises providing a plant comprising a nucleotide sequence encoding N-acetyl neuraminic acid (Neu5Ac) synthase or Neu5Ac lyase, and expressing the nucleotide sequence thereby synthesizing sialic acid. The plant may also co-express a nucleotide sequence encoding one or more than one of an epimerase, a CMP-Neu5Ac synthase, a CMP-Neu5Ac transporter and a sialyltransferase.

Synthesis of sialic acid in plants

A method of synthesizing sialic acid in plants, and plants capable of synthesizing sialic acid is provided. Furthermore, a method of producing sialylated protein in a plant is also provided. The method to synthesize sialic acid comprises providing a plant comprising a nucleotide sequence encoding N-acetyl neuraminic acid (Neu5Ac) synthase or Neu5Ac lyase, and expressing the nucleotide sequence thereby synthesizing sialic acid. The plant may also co-express a nucleotide sequence encoding one or more than one of an epimerase, a CMP-Neu5 Ac synthase, a CMP-Neu5Ac transporter and a sialyltransferase.

Growing community of inventors

Chavannes, Switzerland

Stéphanie Aquin