Dynavax Technologies Corporation

Cell Therapeutics, Inc.

Stewart D Chipman

Radwan Kiwan

Robert L Coffman

Melissa A Kachura

Jack W Singer

David W Leung

Marc Besman

Samuel Zalipsky

Gary S Ott

John A DeMattei

John Demattei

Disclosed are alkyl chain modified 1H-imidazoquinoline compounds, derivatives and analogs thereof, as Toll-like receptor-7 and -8 agonists for enhancing immune responses. Also provided are methods of making pharmaceutical compositions containing these compounds. The present disclosure also describes methods of use for the alkyl chain modified 1H-imidazoquinoline compounds, derivatives and analogs thereof, and pharmaceutical compositions containing these compounds for the treatment of disease in a subject.

Alkyl chain modified imidazoquinoline TLR7/8 agonist compounds and uses thereof

The present disclosure relates to cleavable conjugates (for example, particle-based or antibody-based conjugates) of TLR7/8 agonists (for example, 1H-imidazo[4,5-c]quinoline derivatives) containing a conjugation linker, a cleavable linker, and a self-eliminating linker. The present disclosure also related to methods for preparation of the cleavable conjugates, uses thereof for stimulating an effective immune response, and uses thereof for the treatment of cancer.

Cleavable conjugates of TLR7/8 agonist compounds, methods for preparation, and uses thereof

Disclosed are biologically active protein conjugates that comprise a biologically active polypeptide coupled via a peptide bond to a polypeptide comprising from 2 to about 500 units of a repeating peptide motif, wherein the biologically active protein conjugate exhibits a modified plasma half-life compared to the intrinsic half-life of the unconjugated biologically active polypeptide or protein. Also disclosed are methods of making and using the conjugated proteins, as well as methods for determining whether a given conjugate exhibits a modified half life relative to the intrinsic half life of the unconjugated polypeptide.

Conjugates of biologically active polypeptides having an increased in vivo half-life

Conjugates of biologically active proteins having a modified in vivo half-life

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Bainbridge Island, WA, United States of America

Stewart D Chipman